2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. MLS-2064

MLS-2064 是一种 3'-取代的 7-卤代靛玉红，具有抗肿瘤的活性。MLS-2064 可诱导不依赖 caspase 的细胞死亡。MLS-2064 可在多种人类癌细胞系中诱导剂量依赖性细胞死亡。MLS-2064 对 CDK1 和 CDK5 激酶无显著抑制活性，对 GSK-3 激酶仅具有弱抑制活性 (IC50: 5 μM)。MLS-2064 可用于结肠癌、乳腺癌、肺癌、前列腺癌、肝癌、神经母细胞瘤的相关研究。

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MLS-2064

MLS-2064 Chemical Structure

CAS No. : 906660-74-0

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MLS-2064 相关抗体

Top Publications Citing Use of Products

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MLS-2064 is a 3'-substituted 7-haloindirubin with antitumor activity. MLS-2064 induces caspase-independent cell death. MLS-2064 induces dose-dependent cell death in various human cancer cell lines. MLS-2064 shows no significant inhibitory activity against CDK1 and CDK5 kinases, and only weak inhibitory activity against GSK-3 kinase (IC50: 5 μM). MLS-2064 can be used in research related to colon cancer, breast cancer, lung cancer, prostate cancer, liver cancer, and neuroblastoma[1].

体外研究
(In Vitro)

MLS-2064 (compound 13j) (8 h) 可强效降低多种人类肿瘤细胞系及胚胎肾细胞系的存活率[1]。
MLS-2064 (48 h) 可在 SH-SY5Y 细胞中诱导不依赖 caspase 的细胞死亡，因其细胞活力抑制活性不受 caspase 抑制剂 Q-VD-OPh 的影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MLS-2064 相关抗体:

Cell Viability Assay[1]

Cell Line: HT-29, HCT116 colon cancer, MDA-MB-231 breast cancer, A549 lung cancer, PC3 prostate cancer, 5L, BP8, F1, Huh7 hepatoma, HEK293 embryonic kidney cells
Concentration: /
Incubation Time: 48 h
Result: Exhibited the following IC50 values for cell viability inhibition after 48 h: HT-29 (6.3 μM), HCT116 (5.4 μM), MDA-MB-231 (5.3 μM), A549 (5.9 μM), PC3 (6.1 μM), 5L (5.2 μM), BP8 (5.6 μM), F1 (1.7 μM), Huh7 (5.3 μM), HEK293 (5.0 μM).
分子量

541.27

Formula

C22H24BrCl2N5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MLS-2064 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MLS-2064906660-74-0MLS2064MLS 2064GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3lung cancerprostate cancerCDK5breast cancerhuman cancer cell linescaspase-independent cell deathSH-SY5Y cellsCDK1colon cancerInhibitorinhibitorinhibit

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目录号：
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