2. Anti-infection
  3. Parasite
  4. MMV665917

MMV665917 是一种口服有效的哌嗪衍生物，具有抗隐孢子虫病活性，其 EC90 为 15 μM。MMV665917 在感染人源隐孢子虫的悉生猪模型中显著降低了寄生虫数量，减少卵巢排出、缓解腹泻症状并减轻肠道黏膜损伤。MMV665917 可用于研究隐孢子虫病。

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MMV665917

MMV665917 Chemical Structure

CAS No. : 904576-65-4

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MMV665917 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMV665917 is an orally active piperazine derivative with anti-Cryptosporidium parvum activity with an EC90 of 15 μM. MMV665917 significantly reduces the parasite load in a porcine model infected with C. hominis, decreases ovarian excretion, alleviates diarrhea symptoms and reduces intestinal mucosal damage. MMV665917 can be used for research on Cryptosporidium parvum disease[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-8 CC50
> 100 μM
Compound: 1; MMV665917
Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay
[PMID: 34342443]
Huh-7 CC50
> 100 μM
Compound: GNF-Pf-3446
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
[PMID: 18579783]
分子量

357.80

Formula

C16H16ClN7O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMV665917 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMV665917904576-65-4MMV 665917MMV-665917Parasiteanimal modelCryptosporidium hominisgnotobiotic pigsInhibitorinhibitorinhibit

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目录号：
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