2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Dihydrofolate reductase (DHFR)
  4. MMV675968

MMV675968 是鲍曼不动杆菌 (A. baumannii) 二氢叶酸还原酶 (AbDHFR) 抑制剂 (IC50=8.5 nM)，对人 DHFR 具有选择性。MMV675968 可抑制隐孢子虫、疟原虫和大肠杆菌的二氢叶酸还原酶，破坏胸苷酸循环与叶酸生物合成通路。MMV675968 可抑制多株鲍曼不动杆菌的生长，包括临床分离株和环境分离株。MMV675968 可用于鲍曼不动杆菌感染的相关研究。

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MMV675968

MMV675968 Chemical Structure

CAS No. : 159308-73-3

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MMV675968 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MMV675968 is an inhibitor of Acinetobacter baumannii dihydrofolate reductase (AbDHFR) with an IC50 of 8.5 nM, and it exhibits selectivity against human DHFR. MMV675968 inhibits dihydrofolate reductase in Cryptosporidium, Plasmodium, and Escherichia coli, disrupting the thymidylate cycle and folate biosynthesis pathway. MMV675968 inhibits the growth of multiple A. baumannii strains, including clinical isolates and environmental isolates. MMV675968 is applicable to research related to A. baumannii infections[1].

体外研究
(In Vitro)

MMV675968 可选择性抑制 A. baumannii DHFR，而非人源 DHFR，其中针对 A. baumannii DHFR 的 IC50 为 8.5 nM，针对人源 DHFR 的 IC50 为 492.4 nM[1]。
MMV675968 (0.6-10 μM; 18 h) 可抑制鲍曼不动杆菌 (A. baumannii) Mahidol、Naval-81、H72721 和 3-137 菌株的生长，其 IC50 值为 0.6-2.7 μM，IC90 值为 0.7-3.9 μM，MIC 值为 1.6-10 μM[1]。
MMV675968 (10 μM; 18 h) 可抑制表达 A. baumannii DHFR 的 E. coli PA414 替代细胞的生长，但对表达人源 DHFR 的该细胞无此作用[1]。
MMV675968 (10 μM; 90 min) 抑制鲍曼不动杆菌 Mahidol、Naval-81、H72721 和 3-137 菌株中的内源性 DHFR 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MMV675968 相关抗体:
分子量

359.81

Formula

C17H18ClN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MMV675968 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MMV675968159308-73-3MMV 675968MMV-675968BacterialDihydrofolate reductase (DHFR)human DHFRCryptosporidiumdihydrofolate reductaseclinical isolatesPlasmodiumfolate biosynthetic pathwayAbDHFRAcinetobacter baumanniithymidylate cycleEscherichia coliInhibitorinhibitorinhibit

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