2. MAPK/ERK Pathway JAK/STAT Signaling Apoptosis Cell Cycle/DNA Damage Epigenetics
  3. MNK Pim Apoptosis Caspase Eukaryotic Initiation Factor (eIF) PARP c-Myc
  4. MNK/PIM-IN-2

MNK/PIM-IN-2 是一种 Mnk/Pim 激酶抑制剂，其 Mnk1 IC50 为 32 nM，Mnk2 IC50 为 3 nM，Pim1 IC50 为 37 nM。MNK/PIM-IN-2 可降低 p-eIF4E 和 p-4EBP1 的水平。MNK/PIM-IN-2 可诱导白血病细胞发生细胞周期阻滞、凋亡 (apoptosis) 并产生抗增殖作用。MNK/PIM-IN-2 可用于白血病的相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

MNK/PIM-IN-2

MNK/PIM-IN-2 Chemical Structure

CAS No. : 3081482-46-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MNK/PIM-IN-2 相关抗体

Top Publications Citing Use of Products

查看 MNK 亚型特异性产品:

查看所有亚型
MNK1 MNK2 MNK

查看 Pim 亚型特异性产品:

查看所有亚型
PIM1 PIM2 PIM3

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MNK/PIM-IN-2 is a Mnk/Pim kinase inhibitor with an IC50 of 32 nM for Mnk1, 3 nM for Mnk2, and 37 nM for Pim1. MNK/PIM-IN-2 reduces the levels of p-eIF4E and p-4EBP1. MNK/PIM-IN-2 induces cell cycle arrest, apoptosis (apoptosis) and exerts antiproliferative effects in leukemia cells. MNK/PIM-IN-2 can be used in studies related to leukemia[1].

体外研究
(In Vitro)

MNK/PIM-IN-2 (compound 2j) (72 h) 可抑制人白血病细胞系 MOLM-13、THP-1、U937 和 K562 的增殖[1]。
MNK/PIM-IN-2 (1-2 μM; 12-24 h) 可诱导人白血病细胞 MOLM-13 和 K562 发生 G0/G1 期阻滞[1]。
MNK/PIM-IN-2 (1-2 μM; 12-24 h) 可诱导人白血病细胞系 MOLM-13 发生凋亡，但对人白血病细胞系 K562 未诱导出显著的凋亡效应[1]。
MNK/PIM-IN-2 (2 μM; 12-24 h) 可抑制人白血病细胞 MOLM-13 和 K562 中的 Pim/Mnk 信号通路，降低 p-eIF4E 和 p-4EBP1 水平，下调 Mcl-1 和 c-Myc 的表达，并诱导 MOLM-13 细胞中的 PARP 裂解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MNK/PIM-IN-2 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Human leukemia cell lines (MOLM-13, THP-1, U937, K562)
Concentration: /
Incubation Time: 72 h
Result: Exhibited potent antiproliferative activity against MOLM-13 cells with a GI50 value of 0.19 μM.
Exhibited potent antiproliferative activity against THP-1 cells with a GI50 value of 1.04 μM.
Exhibited potent antiproliferative activity against U937 cells with a GI50 value of 0.59 μM.
Exhibited potent antiproliferative activity against K562 cells with a GI50 value of 0.70 μM.

Cell Cycle Analysis[1]

Cell Line: Human leukemia cell lines (MOLM-13, K562)
Concentration: 1, 2 μM
Incubation Time: 12 h (MOLM-13); 24 h (K562)
Result: Induced G0/G1 phase arrest in MOLM-13 cells at 1 μM for 12 h, with 65.32% of cells in G0/G1.
Caused substantial accumulation in the sub-G1 phase in MOLM-13 cells at 2 μM for 12 h, with 40.44% of cells in sub-G1.
Induced G0/G1 phase arrest in K562 cells at 1 μM for 24 h.
药代动力学
(Parmacokinetics)
Species Dose Route Cmax T1/2 AUC0-last Bioavailability
Rat[1] 2 mg/kg i.v. 247 ng/mL 5.23 h 500 ng·h/mL /
Rat[1] 10 mg/kg i.p. 357 ng/mL 5.36 h 2235 ng·h/mL 90.31 %
体内研究
(In Vivo)

MNK/PIM-IN-2 (10-20 mg/kg，持续 2 周) 在 MOLM-13 异种移植模型中展现出强效的体内抗白血病活性，且未观察到急性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb-c/nu (female) with subcutaneous MOLM‑13 cell inoculation to establish leukemia xenografts[1]
Dosage: 10 mg/kg; 20 mg/kg
Administration: daily; 2 weeks
Result: Suppressed tumor growth with an inhibition rate of 57.1%.
Suppressed tumor growth with an inhibition rate of 72.6%.
Reduced Ki67 expression in tumor tissues.
Upregulated cleaved-caspase 3 levels in tumor tissues.
Caused no significant changes in mouse body weight during administration.
Showed no abnormal changes in major organs via pathological analysis.
分子量

489.54

Formula

C26H28FN7O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MNK/PIM-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MNK/PIM-IN-23081482-46-1MNKPimApoptosisCaspaseEukaryotic Initiation Factor (eIF)PARPc-MycMitogen activated protein kinase interacting kinaseMAP kinase interacting kinaseMAPK interacting kinasePim kinasespoly ADP ribose polymerase MycMnk1Mnk2U937K562Pim1leukemia cellsCLK1THP-1MOLM-13CLK4Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MNK/PIM-IN-2
目录号：
HY-182957
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z