2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Monardic acid A

Monardic acid A 是 AChE 的选择性抑制剂，对电鳗来源 AChE 的 IC50 为 53.1 μM。Monardic acid A 对人红细胞 AChE 抑制活性较弱 (IC50 >100 μM)，对 BChE 无明显抑制作用。Monardic acid A 通过抑制 AChE 活性而减少乙酰胆碱分解，同时具有抑制组胺释放和透明质酸酶的活性，发挥抗炎与神经递质调节作用。Monardic acid A 可从肺草 (Pulmonaria officinalis) 和百里香 (Thymus gobicus) 中分离得到，主要应用于抗炎药物、神经退行性疾病相关药物研发。

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Monardic acid A

Monardic acid A Chemical Structure

CAS No. : 1607436-76-9

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Monardic acid A 相关抗体

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AChE BChE

  • 生物活性

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  • 参考文献

生物活性

Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases[1][2].

IC50 & Target

AChE

 

分子量

538.46

Formula

C27H22O12
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Monardic acid A 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Monardic acid A1607436-76-9Cholinesterase (ChE)Inhibitorinhibitorinhibit

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