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  3. Monasfluore A

Monasfluore A 是一种氮杂菲酮类衍生物,具有抗氧化活性。Monasfluore A 可抑制 LPS 诱导的一氧化氮生成。Monasfluore A 可清除 DPPH 和超氧阴离子自由基。Monasfluore A 可在氧化损伤的结肠腺癌细胞中发挥细胞抗氧化活性。Monasfluore A 对人喉癌细胞和结肠腺癌细胞无抗增殖作用。

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Monasfluore A

Monasfluore A Chemical Structure

CAS No. : 1004537-75-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Monasfluore A is an azaphenanthrenone derivative with antioxidant activity. Monasfluore A inhibits LPS-induced nitric oxide production. Monasfluore A scavenges DPPH and superoxide anion free radicals. Monasfluore A exerts cellular antioxidant activity in oxidatively damaged colon adenocarcinoma cells. Monasfluore A shows no antiproliferative effect on human laryngeal cancer cells and colon adenocarcinoma cells[1][2].

体外研究
(In Vitro)

Monasfluore A (compound 5) (6.25-100 μg/mL; 3 days) 对人喉癌细胞 (HEp-2) 和人结肠腺癌细胞 (WiDr) 无抗增殖活性,两种细胞系的 IC50 均 > 100 μg/mL[1]
Monasfluore A (5-20 μg/mL; 24 h) 可显著且呈剂量依赖性地抑制 Lipopolysaccharide (LPS) (HY-D1056) 诱导的小鼠巨噬细胞 (RAW 264.7) 中一氧化氮的生成,其 IC50 为 12.8 μg/mL,同时能维持较高的细胞活力[1]
Monasfluore A (0.02-0.10 mg/mL; 0.2-18 mg/mL; 0-5 mg/mL),一种从功能曲中分离纯化的物质,可通过清除 DPPH、清除超氧阴离子及抑制蛋黄脂蛋白过氧化的方式,在体外呈现浓度依赖性的抗氧化活性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: human laryngeal carcinoma (HEp-2) cells, human colon adenocarcinoma (WiDr) cells
Concentration: 6.25, 12.5, 25, 50, 100 μg/mL
Incubation Time: 3 days
Result: Exhibited no anti-proliferative effects on HEp-2 or WiDr cells, with an IC50 value greater than 100 μg/mL for both cell lines.
分子量

356.41

Formula

C21H24O5

CAS 号
结构分类
初始来源

Monascus purpureus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Monasfluore A
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HY-N11737
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