2. Neuronal Signaling
  3. Amyloid-β
  4. (Mor-Cor)Ag(III)

(Mor-Cor) Ag (III) 是一种可穿透血脑屏障的银 (III) 咕啉配合物，能够穿透血脑屏障。(Mor-Cor) Ag (III) 可清除 Aβ42 诱导产生的活性氧，破坏 Aβ42 的聚集，从而减轻 Aβ42 诱导的神经元过度活动。(Mor-Cor) Ag (III) 可用于阿尔茨海默病的研究。

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(Mor-Cor)Ag(III)

(Mor-Cor)Ag(III) Chemical Structure

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(Mor-Cor)Ag(III) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Mor-Cor)Ag(III) is a blood-brain barrier-penetrant silver(III) corrole complex that penetrates the blood-brain barrier. (Mor-Cor)Ag(III) scavenges reactive oxygen species induced by Aβ42 and disrupts Aβ42 aggregation, attenuating Aβ42-induced neuronal hyperactivity. (Mor-Cor)Ag(III) can be used for the research of Alzheimer's disease[1].

体外研究
(In Vitro)

(Mor-Cor) Ag (III)(1-6 μM) 在浓度高达 6 μM 时对 HT-22 小鼠海马细胞无毒性，其中 1-2 μM 是发挥神经保护作用的最优浓度[1]。
(Mor-Cor) Ag (III) (2 μM) 相较于 (Cor) Ag (III)[1]，对原代大鼠神经元-星形胶质细胞培养物具有更优异的神经保护作用，可抵御 Aβ42 诱导的神经突断裂、胶质增生和神经毒性。
(Mor-Cor) Ag (III) (2 μM) 可减弱 Aβ1-42 诱导的原代大鼠皮质神经元过度兴奋[1]。
(Mor-Cor) Ag (III)(2 μM) 可降低暴露于 Aβ42 寡聚体的原代大鼠神经元-星形胶质细胞培养物中的神经元死亡[1]。
(Mor-Cor) Ag (III) 2 μM 可有效降低原代大鼠神经元-星形胶质细胞培养体系中由 Aβ42 诱导的 ROS 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Mor-Cor)Ag(III) 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Mice[1] 200 μg i.v. Plasma Concentration 37.2 μg/mL
Mice[1] 200 μg i.v. Plasma Concentration 36.7 μg/mL
Mice[1] 200 μg i.v. Plasma Concentration 36.0 μg/mL
Mice[1] 200 μg i.v. Plasma Concentration 36.8 μg/mL
体内研究
(In Vivo)

(Mor-Cor) Ag (III) (200 μg；静脉注射；单剂量或连续 7 天每日给药) 可在 3×Tg-AD 小鼠中发挥神经保护作用，能够增加树突密度并减少 Aβ42 沉积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3×Tg-AD (APPSwe, tauP301L) (3-6 months old)[1]
Dosage: 200 μg (24-h single dose; 7-day daily dose)
Administration: i.v.; single dose (24 h); daily (7 consecutive days)
Result: Increased dendritic density (measured by MAP2 intensity) in the cortex significantly after single 24-h treatment compared to vehicle; Enhanced MAP2 immunoreactivity in the cortex significantly after 7-day daily treatment; Reduced Aβ42 aggregation in both the hippocampus and cortex significantly after 7-day daily treatment.
分子量

810.65

Formula

C45H32AgN7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Mor-Cor)Ag(III) 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Mor-Cor)Ag(III)Amyloid-ββ-amyloid peptideAβAbetaGFAPneuronal hyperactivityreactive oxygen speciesHT-22 mouse hippocampal cellsastrocytesprimary rat neuron-astrocyte culturesAβ42blood-brain barrierneuronal death3×Tg-AD mouse modelsInhibitorinhibitorinhibit

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