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  4. Moracenin D

Moracenin D 是一种天然的黄酮。

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Moracenin D

Moracenin D Chemical Structure

CAS No. : 78277-79-9

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Moracenin D 相关抗体

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  • 生物活性

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生物活性

Moracenin D is a natural flavonoid.

IC50 & Target[1]

Nurr1/NR4A2

 

α-synuclein

 

体外研究
(In Vitro)

Moracenin D (0.16-4 μM；24 h) 可保护 SH-SY5Y 细胞免受多巴胺诱导的细胞死亡 (EC50 = 3.6 μM)[1]。
Moracenin D (0.16-4 μM；9-15 h) 以剂量依赖方式上调多巴胺处理细胞中 nurr1 的表达，并下调 α-synuclein 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Moracenin D 相关抗体:

Cell Viability Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 24 h
Result: Protected SH-SY5Y cells against dopamine-induced cell death with an EC₅₀ of 3.6 ± 0.9 μM

RT-PCR[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 9 h
Result: Up-regulated nurr1 mRNA expression and down-regulated α-synuclein mRNA expression in a dose-dependent manner compared to the dopamine-alone group

Western Blot Analysis[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 0.16-4 μM
Incubation Time: 15 h
Result: Increased nurr1 protein expression and decreased α-synuclein protein expression in a dose-dependent manner compared to the dopamine-alone group
分子量

710.72

Formula

C40H38O12
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Moracenin D 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Moracenin D78277-79-9Drug DerivativeDrug derivativehuman neuroblastoma cellsNurr1 mRNANurr1 agonistSH-SY5Y cellsα-synuclein regulatordopamine-exposed cellsα-synuclein mRNAParkinson’s diseaseneuroprotective agentdopamine-induced cell deathInhibitorinhibitorinhibit

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Moracenin D
目录号：
HY-N16831
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