2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. MPAM-15

MPAM-15 是一种可穿透血脑屏障的阿片受体​泛正构变构调节剂 (PAM)，相比 δOR 和 κOR，对 μOR 具有 ≥16 倍的选择性。MPAM-15 可作为抗伤害感受增强剂和镇痛剂，在小鼠模型中通过脑室内给药和腹腔给药均观察到其活性。MPAM-15 可用于疼痛相关研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

MPAM-15

MPAM-15 Chemical Structure

CAS No. : 312632-55-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

MPAM-15 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MPAM-15 is a blood-brain barrier-penetrant pan-orthosteric allosteric modulator (PAM) of opioid receptors, with ≥16-fold selectivity for μOR over δOR and κOR. MPAM-15 acts as an anti-nociceptive potentiator and analgesic, and its activity is observed in mouse models via both intracerebroventricular and intraperitoneal administration. MPAM-15 is applicable for pain-related research[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

 

体外研究
(In Vitro)

MPAM-15 (10 μM) 可增强表达人 μ 阿片受体 (μOR) 的 HEK293T 细胞中 DAMGO 诱导的 cAMP 抑制作用，将该激动剂的 pEC50 从 8.8 提升至 9.9[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MPAM-15 相关抗体:
体内研究
(In Vivo)

MPAM-15 (1.5-5 μM；侧脑室给药；单次给药) 在 52℃ 热板试验中可使小鼠产生剂量依赖性镇痛作用[1]。
MPAM-15 (15-30 mg/kg；腹腔注射；单次给药) 本身无镇痛作用，但能显著增强低剂量吗啡的镇痛效果，且可避免吗啡引发的副作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male and female, 8 to 10 weeks old)[1]
Dosage: 1.5 μM; 2.5 μM; 5 μM
Administration: i.c.v.; single dose
Result: Increased response latencies to ~45 s (1.5 μM), ~55 s (2.5 μM), and ~50 s (5 μM) at 10 minutes post-injection.
Increased response latencies to ~35 s (1.5 μM), ~45 s (2.5 μM), and ~40 s (5 μM) at 15 minutes post-injection.\nEnhanced morphine-induced antinociception in a dose-dependent manner, with the 5 μM dose producing the longest and highest analgesic effect.
Increased response latency to ~70 s at 10 minutes post-injection, ~65 s at 15 minutes, and ~45 s at 30 minutes post-injection (5 μM dose).
Animal Model: C57BL/6J (male and female, 8 to 10 weeks old)[1]
Dosage: 15 mg/kg; 30 mg/kg
Administration: i.p.; single dose
Result: Significantly enhanced the analgesic effect of low-dose morphine (3 and 5 mg/kg), and the combined effect was comparable to that of high-dose morphine (10 mg/kg) used alone.
Did not cause constipation, respiratory depression, or addiction.
分子量

450.95

Formula

C27H27ClO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MPAM-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPAM-15312632-55-6MPAM15MPAM 15Opioid ReceptorpainHEK293T cellsanalgesiaopioid receptorsκORmouse modelsμORantinociceptioncAMPδORInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
MPAM-15
目录号：
HY-181956
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z