2. Antibody-drug Conjugate/ADC Related
  3. ADC Antibody
  4. MRG004A Antibody

MRG004A Antibody (HuSC1-39) 是一种靶向组织因子 (TF) 的单克隆抗体抑制剂。MRG004A Antibody 可用于合成抗体-药物偶联物 (ADC) MRG004A。MRG004A Antibody 可用于开展癌症相关研究。

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MRG004A Antibody

MRG004A Antibody Chemical Structure

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MRG004A Antibody 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MRG004A Antibody (HuSC1-39) is a monoclonal antibody inhibitor targeting tissue factor (TF). MRG004A Antibody can be used to synthesize the antibody-drug conjugate (ADC) MRG004A. MRG004A Antibody can be used to research related to cancer[1].

反应种属

Human
体外研究
(In Vitro)

MRG004A Antibody 可通过蛋白酶体依赖的 TREX1 降解激活 STING 通路，从而在 HPAF-II、BxPC3、MDA-231 和 HCC1806 细胞中诱导胞质微核积累、增强 STING 通路磷酸化水平，并以 STING 依赖的方式上调 CCL5 和 CXCL10 mRNA 的表达[1]。
MRG004A Antibody (15 μg/mL; 24 h for cytokine secretion, 48 h for viability) 可增加与 PBMC 共培养的 HPAF-II、BxPC3 或 MDA-231 细胞中 CXCL10 和 IFN−γ 的分泌，并降低肿瘤细胞的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MRG004A Antibody 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human PDAC HPAF-II, BxPC3 cells, human TNBC MDA-231 cells, PBMCs
Concentration: 15 μg/mL (cytokine secretion); 15 μg/mL (tumor cell viability)
Incubation Time: 24 h (cytokine secretion); 48 h (tumor cell viability)
Result: Increased secretion of CXCL10 and IFN-γ.
Reduced tumor cell viability.
体内研究
(In Vivo)

MRG004A Antibody (HuSC1-3) (10 mg/kg; i.v.; 2 doses on days 14 and 18 post-implantation) 可显著抑制裸鼠中原位 HPAF-II 胰腺导管腺癌的生长，激活 STING 固有免疫通路，减少促肿瘤信号传导，增加免疫效应细胞浸润，并降低 TREX1 蛋白水平[1]。
MRG004A Antibody (10 mg/kg; i.v.) 可抑制裸鼠皮下 BxPC3 胰腺导管腺癌的生长，激活 STING 固有免疫通路，减少促肿瘤信号传导，并降低 TREX1 蛋白水平[1]。
MRG004A Antibody (10 mg/kg; i.v.) 可抑制裸鼠皮下 HPAF-II 胰腺导管腺癌的生长，激活 STING 固有免疫通路，减少促肿瘤信号传导，并降低 TREX1 蛋白水平[1]。
MRG004A Antibody (10 mg/kg; i.v.) 可抑制裸鼠皮下 HCC1806 三阴性乳腺癌的生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice[1]
Dosage: 10 mg/kg
Administration: i.v.
Result: Inhibited tumor growth.
Reduced TF, P-ERK, and P-AKT relative intensity in tumor sections.
Increased P-STING and P-TBK1 relative intensity in tumor sections.
Nearly eliminated TREX1 protein staining in tumor tissue.\nInhibited tumor growth.
Reduced TF, P-ERK, and P-AKT relative intensity in tumor sections.
Increased P-STING and P-TBK1 relative intensity in tumor sections.
Nearly eliminated TREX1 protein staining in tumor tissue.
Animal Model: Nude mice[1]
Dosage: 10 mg/kg
Administration: i.v.
Result: Inhibited tumor growth.
基因 ID

2152  [NCBI]

Accession
靶点

F3/Factor III/Tissue Factor/CD142
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MRG004A Antibody 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRG004A AntibodyADC AntibodyCCL5cGAS-STING pathwayTREX1CXCL10HPAF-IItissue factorIRF3pancreatic ductal adenocarcinomatriple-negative breast cancerBxPC3Inhibitorinhibitorinhibit

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