2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Mu opioid receptor antagonist 9

Mu opioid receptor antagonist 9 是一种强效、选择性强且可穿透血脑屏障的 μ- 阿片受体 (MOR) 拮抗剂，其 Ki 为 77.3 nM。Mu opioid receptor antagonist 9 对 κ- 阿片受体 (KOR) 和 δ- 阿片受体 (DOR) 具有选择性。Mu opioid receptor antagonist 9 能有效阻断精神活性物质的镇痛作用。Mu opioid receptor antagonist 9 可以逆转精神活性物质诱导的小鼠呼吸抑制。Mu opioid receptor antagonist 9 可用于阿片类药物使用障碍 (OUD) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Mu opioid receptor antagonist 9

Mu opioid receptor antagonist 9 Chemical Structure

CAS No. : 3058600-77-1

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Mu opioid receptor antagonist 9 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mu opioid receptor antagonist 9 is potent, selective and CNS-pentrant mu-opioid receptor (MOR) antagonist with a Ki of 77.3 nM. Mu opioid receptor antagonist 9 exhibits selectivity over kappa-opioid receptor (KOR), and delta-opioid receptor (DOR). Mu opioid receptor antagonist 9 effectively blocks the antinociceptive effects of psychoactive substances. Mu opioid receptor antagonist 9 can reverse psychoactive substances-induced respiratory depression in mice. Mu opioid receptor antagonist 9 can be used for the research of Opioid Use Disorder (OUD)[1].

IC50 & Target[1]

μ Opioid Receptor/MOR

77.3 nM (Ki)

κ Opioid Receptor/KOR

681 nM (Ki)

δ Opioid Receptor/DOR

4182 nM (Ki)

体外研究
(In Vitro)

Mu opioid receptor antagonist 9 (compound 53) (15 分钟) 抑制 DAMGO (HY-P0210) 和精神活性物质在 mMOR-CHO 细胞中诱导的钙流，IC50 值分别为 33.6 和 4.51 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mu opioid receptor antagonist 9 相关抗体:
体内研究
(In Vivo)

Mu opioid receptor antagonist 9 (1-10 mg/kg；皮下注射；单次给药) 可阻断精神活性物质在小鼠温水尾浸疼痛模型中的镇痛作用[1]。
Mu opioid receptor antagonist 9 (1-32 mg/kg；皮下注射；精神活性物质给药后 20 分钟单次给药) 在小鼠全身容积描记法研究中显示出对精神活性物质诱导的呼吸抑制的强效逆转作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice(6-8-week-old) subcutaneous injected with psychoactive substances[1]
Dosage: 1, 2, 4, 5, 10 mg/kg
Administration: s.c.; single dose
Result: Blocked the antinociception of morphine at a dose of 10 mg/kg. showed AD50s of 2.02 mg/kg (95% CL) against 10 mg/kg morphine, and 4.02 mg/kg (95% CL) against 0.1 mg/kg fentanyl.
Animal Model: Male Swiss Webster mice(6-8-week-old) subcutaneous injected with psychoactive substances[1]
Dosage: 1, 3.2, 10, 32 mg/kg
Administration: s.c.; single dose at 20min post-fentanyl
Result: Demonstrated a potent reversal effect on fentanyl-induced respiratory depression at both 10 and 32 mg/kg doses. Increased both respiratory frequency and tidal volume. Showed beneficial effect within a short time frame, appearing 10 min postadministration for the 32 mg/kg dose and 15 min postadministration for the 10 mg/kg dose.
分子量

374.90

Formula

C21H27ClN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mu opioid receptor antagonist 9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mu opioid receptor antagonist 93058600-77-1Mu opioid receptor antagonist9Mu opioid receptor antagonist-9Opioid Receptorpotent mu opioid receptor antagonistantagonism studiesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Mu opioid receptor antagonist 9
目录号：
HY-179282
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z