2. Cell Cycle/DNA Damage
  3. Endonuclease
  4. MU262

MU262 是一种 MUS81 抑制剂，IC50 值为 0.87 μM。MU262 通过非干扰 DNA 结合的方式直接抑制 MUS81 催化活性，可诱导肿瘤细胞基因组不稳定性、特异性抑制 HR/BIR 修复通路。MU262 与 Cisplatin (HY-17394) 联用能显著增强化疗杀伤效果。MU262 可用作研究 MUS81 功能的化学生物学工具，也可作为先导化合物，用于开发利用癌细胞 DNA 修复缺陷的抗癌疗法。

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MU262

MU262 Chemical Structure

CAS No. : 1846587-13-0

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MU262 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MU262 is a MUS81 inhibitor with an IC50 value of 0.87 μM. MU262 directly inhibits the catalytic activity of MUS81 without interfering with DNA binding, induces genomic instability in tumor cells, and specifically inhibits the HR/BIR repair pathway. The combination of MU262 with Cisplatin (HY-17394) significantly enhances the chemotherapeutic killing effect. MU262 serves as a chemical biology tool for studying MUS81 function, and also acts as a lead compound for the development of anticancer therapies that exploit DNA repair defects in cancer cells[1].

体外研究
(In Vitro)

MU262 (0.5-5 μM; 0-72 h) 可抑制 U2OS BIR-GFP 细胞中的断裂诱导复制，其 IC50 为 1.53 μM[1]。
MU262 (1-5 μM; 0-72 h) 可抑制 U2OS DR-GFP 细胞中的同源重组[1]。
MU262 (3-12 μM; 48 h) 可在 U2OS 细胞中诱导微核形成[1]。
MU262 (72 h) 可在 U2OS 细胞中诱导持续性 DNA 损伤，该效应通过 γH2AX 灶形成增加得以检测[1]。
MU262 (10-12 天) 可降低 U2OS 细胞的克隆形成存活率[1]。
MU262 (2-16 μM; 96-120 h) 可与 Cisplatin (HY-17394) 协同作用以降低 U2OS 细胞的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MU262 相关抗体:

Cell Viability Assay[1]

Cell Line: U2OS cells
Concentration: 2, 8, 16 μM (in combination with Cisplatin 0-5 μM)
Incubation Time: 96-120 h
Result: Dose-dependently enhanced cisplatin-induced cytotoxicity, reducing cell viability more effectively than cisplatin alone.
分子量

374.37

Formula

C20H15FN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MU262 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU2621846587-13-0MU 262MU-262EndonucleaseU2OS cellsEME1MUS81micronucleihomologous recombination DNA repairbreak-induced replicationMUS81-EME1 complexγH2AX focicisplatinInhibitorinhibitorinhibit

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目录号：
HY-181840
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