2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. Mudanpioside E

Mudanpioside E 是一种口服有效的芍药苷型单萜糖苷类抗过敏剂，对 IgE 介导的 β-己糖胺酶 (β-hexosaminidase) 释放的 IC50 为 40.34 μM。Mudanpioside E 可逆转去芍药根成分的小青龙汤提取物对小鼠被动皮肤过敏反应的抑制作用。Mudanpioside E 本身对被动皮肤过敏反应无活性。Mudanpioside E 可用于过敏性疾病的相关研究。

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Mudanpioside E

Mudanpioside E Chemical Structure

CAS No. : 172705-25-8

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Mudanpioside E 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mudanpioside E is an orally effective paeoniflorin-type monoterpene glycoside antiallergic agent, with an IC50 of 40.34 μM against IgE-mediated β-hexosaminidase release. Mudanpioside E reverses the inhibitory effect of the modified Xiaoqinglong Decoction extract (paeonia root component removed) on passive cutaneous anaphylaxis in mice. Mudanpioside E itself shows no activity against passive cutaneous anaphylaxis. Mudanpioside E can be used in research related to allergic diseases[1][2].

体外研究
(In Vitro)

Mudanpioside E (10.0-100.0 μM) 可强效抑制 RBL-2H3 细胞中 IgE 介导的 β-己糖胺酶释放 (脱颗粒的标志物)，其 IC50 为 40.34 μM，且在浓度高达 100.0 μM 时无细胞毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mudanpioside E 相关抗体:
体内研究
(In Vivo)

Mudanpioside E (0.55 g/kg-2.2 mg/kg; p.o.; 单次给药) 可剂量依赖性地抵消去白芍成分的小青龙汤提取物对小鼠被动皮肤过敏反应 (PCA) 的抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ddY mice (6-week-old, male)[1]
Dosage: 0.55 mg/kg; 1.1 mg/kg; 2.2 mg/kg (all co-administered with Peony root-depleted Shoseiryuto-extract at 0.57 g/kg)
Administration: p.o.; single dose
Result: Significantly counteracted the suppressive effect of Peony root-depleted Shoseiryuto-extract on the PCA reaction in a dose-dependent manner at 0.55, 1.1, and 2.2 mg/kg.
Did not exhibit any effect on the PCA reaction when administered alone at 2.2 mg/kg.
分子量

526.49

Formula

C24H30O13
CAS 号
中文名称

牡丹皮苷E
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mudanpioside E 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mudanpioside E172705-25-8牡丹皮苷EGlycosidasebasophil leukemia cellsallergic diseasesIgE-mediated β-hexosaminidase releasedegranulationPaeonia lactiflora 'Edulis Superba'miceRBL-2H3 cellspassive cutaneous anaphylaxis reactionsInhibitorinhibitorinhibit

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