2. Cytoskeleton
  3. Myosin
  4. Myosin-IN-4

Myosin-IN-4 (Compound 3) 是一种吡啶-2,4-二酮衍生物，是一种心肌肌球蛋白 (myosin) 抑制剂。Myosin-IN-4 对心肌肌球蛋白 ATP 酶具有强烈的抑制活性，其 IC50 值为 0.73 μM。Myosin-IN-4 通过抑制心肌收缩而产生负性肌力作用。Myosin-IN-4 可用于与心肌肌球蛋白相关的心血管疾病的研究。

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Myosin-IN-4

Myosin-IN-4 Chemical Structure

CAS No. : 2823425-92-7

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Myosin-IN-4 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Myosin-IN-4 (Compound 3), a pyridine-2,4-dione derivative, is a myocardial myosin inhibitor. Myosin-IN-4 has a strong inhibitory activity against cardiac myosin ATPase with an IC50 value of 0.73 μM. Myosin-IN-4 exert a negative inotropic effect by inhibiting myocardial contraction. Myosin-IN-4 can be used for the research on cardiovascular diseases related to cardiac myosin[1].

药代动力学
(Parmacokinetics)
Species Dose Route Indicator value
Rat 1 mg/kg i.g.
Rat 0.2 mg/kg i.v. CL 8.11 mL/min/kg
Rat 0.2 mg/kg i.v. C0 0.773 μM
Rat 0.2 mg/kg i.v. Vd 1.6 L/kg
Rat 0.2 mg/kg i.v. T1/2 2.31 h
Rat 0.2 mg/kg i.v. AUC 1.331 μM·h
分子量

284.35

Formula

C17H20N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Myosin-IN-4 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Myosin-IN-42823425-92-7MyosinInhibitorinhibitorinhibit

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