2. NF-κB
  3. NF-κB
  4. (−)-N-Hydroxyapiosporamide

(−)-N-Hydroxyapiosporamide (NHAP) 是一种生物碱，是一种 NF-κB 抑制剂，在体外和体内具有有效的抗肿瘤活性。 (−)-N-Hydroxyapiosporamide 可用于结直肠癌 (CRC) 的研究。

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(−)-N-Hydroxyapiosporamide

(−)-N-Hydroxyapiosporamide Chemical Structure

CAS No. : 1205676-02-3

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(−)-N-Hydroxyapiosporamide 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC)[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
0.93 μM
Compound: NHAP
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HCT-116 IC50
2.8 μM
Compound: NHAP
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37243616]
HCT-15 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HT-29 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
HT-29 IC50
0.61 μM
Compound: NHAP
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
[PMID: 37243616]
RKO IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
SW-620 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
SW480 IC50
0.57 μM
Compound: NHAP
Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
[PMID: 37243616]
分子量

445.51

Formula

C24H31NO7
CAS 号
结构分类
初始来源

Apiospora montagnei
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(−)-N-Hydroxyapiosporamide 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(−)-N-Hydroxyapiosporamide1205676-02-3NHAPNF-κBNuclear factor-κBNuclear factor-kappaBalkaloidantitumorcolorectal cancer (CRC)Inhibitorinhibitorinhibit

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