2. Immunology/Inflammation
  3. NO Synthase
  4. N-Phthaloyl-L-glutamic acid

N-Phthaloyl-L-glutamic acid 是一种口服活性抗炎剂。N-Phthaloyl-L-glutamic acid 可抑制脂多糖 (HY-D1056) (LPS) 诱导的小鼠脾细胞产生一氧化氮。N-Phthaloyl-L-glutamic acid 在体外对肿瘤细胞及 BALB/c 小鼠脾细胞培养均未表现出显著的细胞毒性。N-Phthaloyl-L-glutamic acid 可用于炎症相关研究 。

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N-Phthaloyl-L-glutamic acid

N-Phthaloyl-L-glutamic acid Chemical Structure

CAS No. : 340-90-9

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规格 价格 是否有货 数量
1 g ￥100
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5 g ￥180
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10 g ￥252
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25 g ￥480
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50 g ￥779
In-stock
100 g ￥1250
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Other Forms of N-Phthaloyl-L-glutamic acid:

N-Phthaloyl-L-glutamic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

N-Phthaloyl-L-glutamic acid is an orally active anti-inflammatory agent. N-Phthaloyl-L-glutamic acid inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced nitric oxide production in murine spleen cells. N-Phthaloyl-L-glutamic acid does not exhibit significant cytotoxicity in vitro against tumor cells and BALB/c mice spleen cell culture. N-Phthaloyl-L-glutamic acid can be used for the research of inflammation[1].

体外研究
(In Vitro)

N-Phthaloyl-L-glutamic acid (compound 2f) (25-50 μg/mL；72 h) 可抑制 Lipopolysaccharides (HY-D1056) (LPS) 诱导的一氧化氮生成，并对 BALB/c 小鼠脾细胞表现出较低的细胞毒性[1]。
N-Phthaloyl-L-glutamic acid (25 μg/mL；48 h) 对人肿瘤细胞系 (MDA/MB-435，HCT-8 和 SF-295) 表现出较弱的抗增殖活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

N-Phthaloyl-L-glutamic acid 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA/MB-435, HCT-8, SF-295
Concentration: 25 μg/mL
Incubation Time: 48 h
Result: Inhibited proliferation of MDA/MB-435 cells by 12.92%, HCT-8 cells by 6.52%, and SF-295 cells by 14.42%.
体内研究
(In Vivo)

N-Phthaloyl-L-glutamic acid (compound 2f)(100 mg/kg；口服；单次给药) 在 BALB/c 小鼠 (卡拉胶诱导的气囊模型) 中主要抑制中性粒细胞 (PMNL) 的迁移，其 PMNL 浸润抑制率为 61.7%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c (weight 25-30 g) (carrageenan-induced air pouch model)[1]
Dosage: 100 mg/kg
Administration: p.o.; single dose
Result: Reduced polymorphonuclear leukocyte migration into the air pouch, resulting in 61.7% inhibition of PMNL infiltration.
分子量

277.23

Formula

C13H11NO6
CAS 号
性状

固体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 116.67 mg/mL (420.84 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.6071 mL 18.0356 mL 36.0711 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

N-Phthaloyl-L-glutamic acid 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6071 mL 18.0356 mL 36.0711 mL 90.1778 mL
5 mM 0.7214 mL 3.6071 mL 7.2142 mL 18.0356 mL
10 mM 0.3607 mL 1.8036 mL 3.6071 mL 9.0178 mL
15 mM 0.2405 mL 1.2024 mL 2.4047 mL 6.0119 mL
20 mM 0.1804 mL 0.9018 mL 1.8036 mL 4.5089 mL
25 mM 0.1443 mL 0.7214 mL 1.4428 mL 3.6071 mL
30 mM 0.1202 mL 0.6012 mL 1.2024 mL 3.0059 mL
40 mM 0.0902 mL 0.4509 mL 0.9018 mL 2.2544 mL
50 mM 0.0721 mL 0.3607 mL 0.7214 mL 1.8036 mL
60 mM 0.0601 mL 0.3006 mL 0.6012 mL 1.5030 mL
80 mM 0.0451 mL 0.2254 mL 0.4509 mL 1.1272 mL
100 mM 0.0361 mL 0.1804 mL 0.3607 mL 0.9018 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Phthaloyl-L-glutamic acid340-90-9NO SynthaseNitric oxide synthasesNOSBALB/c mice spleen cell cultureinflammationhuman tumor cell linescarrageenan-induced air pouch modelanti-oral inflammatory agentLPS-induced nitric oxide productionmurine spleen cellstumor cellsN-phthaloyl amino acidnitric oxide productionanti-oral inflammatory activityPMNL infiltration inhibitionBALB/c micelipopolysaccharide-induced nitric oxide production inhibitorPMNL migrationInhibitorinhibitorinhibit

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