2. Others PI3K/Akt/mTOR Epigenetics NF-κB
  3. Drug Derivative AMPK IKK NF-κB
  4. Nandinine

Nandinine 是一种具有口服活性的 Berberine (HY-N0716) 衍生物。Nandinine 可提升 AMPK 活性，抑制 IKKβ/NF-κB 的激活，并调控 IRS-1 的磷酸化。Nandinine 可逆转脂肪因子的异常生成，促进胰岛素介导的葡萄糖摄取，减轻胰岛素抵抗。Nandinine 可改善小鼠的葡萄糖耐量，提升其胰岛素敏感性指数。Nandinine 可用于胰岛素抵抗相关研究。

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Nandinine

Nandinine Chemical Structure

CAS No. : 572-76-9

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Nandinine 相关抗体

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1 BRSK1 BRSK2 HUNK AMPKα

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nandinine is an orally active derivative of Berberine (HY-N0716). Nandinine enhances AMPK activity, inhibits the activation of IKKβ/NF-κB, and regulates the phosphorylation of IRS-1. Nandinine reverses the abnormal production of adipokines, promotes insulin-mediated glucose uptake, and alleviates insulin resistance. Nandinine improves glucose tolerance and increases the insulin sensitivity index in mice. Nandinine can be used in studies related to insulin resistance[1].

IC50 & Target[1]

IKKβ

 

体外研究
(In Vitro)

Nandinine (10 µM; 1 h) 可通过降低促炎性 TNF-α 和 IL-6 水平、恢复抗炎性脂联素水平，显著逆转 Mac-CM 诱导的分化后 3T3-L1 脂肪细胞中脂肪因子分泌失调[1]。
Nandinine (10 µM; 1 h) 可显著抑制 Mac-CM 诱导的分化后 3T3-L1 脂肪细胞中 IKKβ/NF-κB 通路的激活[1]。
Nandinine (10 µM; 预处理 1 小时，与 Mac-CM 共孵育 30 分钟) 可通过调控 IRS-1 磷酸化及下游 PI3K/Akt/GLUT-4 通路活性，显著恢复经 Mac-CM 处理的分化 3T3-L1 脂肪细胞中胰岛素介导的信号传导与葡萄糖摄取[1]。
Nandinine (10 µM; 1 h) 可显著激活正常及 Mac-CM 处理的分化 3T3-L1 脂肪细胞中的 AMPK[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nandinine 相关抗体:

Western Blot Analysis[1]

Cell Line: differentiated 3T3-L1 adipocytes
Concentration: 10 µM
Incubation Time: 1 h pretreatment; 30 min stimulation with Mac-CM
Result: Reversed Mac-CM-induced increases in IKKβ phosphorylation.
Reversed Mac-CM-induced increases in IκBα phosphorylation.
Reversed Mac-CM-induced increases in p65 phosphorylation.
Reversed Mac-CM-induced increases in nuclear p65 expression.
Reduced the Mac-CM-enhanced interaction between IκBα and IKKβ.
All changes were statistically significant at P < 0.01 compared to Mac-CM-only treatment.
体内研究
(In Vivo)

Nandinine (100-200 mg/kg；口服；单次) 可有效改善雄性 ICR 小鼠中 Mac-CM 诱导的葡萄糖耐受不良，并降低其胰岛素抵抗[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 6-8 weeks of age)[1]
Dosage: 100 mg/kg; 200 mg/kg
Administration: p.o.; single dose
Result: Restored glucose disposal compared to Mac-CM-only treated mice.
Reduced the area under the curve for glucose (AUC-G) compared to Mac-CM-only treated mice.
Decreased the homeostasis model assessment of insulin resistance (HOMA-IR) index compared to Mac-CM-only treated mice.
分子量

325.36

Formula

C19H19NO4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nandinine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nandinine572-76-9Drug DerivativeAMPKIKKNF-κBDrug derivativeAMP-activated protein kinaseIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBadipocytesICR micePI3K/Akt pathwayTNF-α3T3-L1 adipocytesIL-6IKKβIRS-1adiponectinInhibitorinhibitorinhibit

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