2. Neuronal Signaling Metabolic Enzyme/Protease
  3. Beta-secretase Cathepsin Amyloid-β
  4. NB-533

NB-533 是一种具有口服活性且可穿透血脑屏障的 BACE-1 抑制剂，对人源靶点的 IC50 为 0.002 μM。NB-533 还可抑制人源组织蛋白酶 D (cathepsin D)，其 IC50 为 0.001 μM。NB-533 可抑制产淀粉样蛋白的淀粉样前体蛋白 (APP) 加工过程，并减少 Aβ40 的释放。NB-533 可降低转基因小鼠脑内 APP 代谢产物 C99 和 Aβ40 的水平。NB-533 可用于阿尔茨海默病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NB-533

NB-533 Chemical Structure

CAS No. : 1146544-18-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

NB-533 相关抗体

Top Publications Citing Use of Products

查看 Beta-secretase 亚型特异性产品:

查看所有亚型
BACE1 BACE2

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC50 of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC50 of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ40 release. NB-533 reduces brain levels of APP metabolite C99 and Aβ40 in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease[1].

IC50 & Target[1]

BACE1

0.002 μM (IC50)

Cathepsin D

0.001 μM (IC50)

体外研究
(In Vitro)

NB-533 可强效抑制人源 BACE-1 酶，其 IC50 为 0.002 μM[1]。
NB-533 可抑制人源 APP 转染 CHO 细胞释放 Aβ40，其 IC50 为 0.024 μM[1]。
NB-533 以 0.001 μM 的 IC50 值抑制人组织蛋白酶 D[1]。
NB-533 在 MDCK mdr1a 细胞中的外排率 (BA/AB) 为 9.4，显示出对 P-糖蛋白的敏感性降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NB-533 相关抗体:
体内研究
(In Vivo)

NB-533 (100 μmol/kg；口服；于 0 小时和 3 小时给药两次) 可使 APP51/16 转基因小鼠的前脑 C99 水平显著降低 20%，脑脊液 Aβ40 水平显著降低 26%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: APP51/16 transgenic mice (expressing wild-type human APP under a brain-specific promoter)[1]
Dosage: 100 μmol/kg
Administration: p.o.; at 0 and 3 hours
Result: Reached brain levels of 0.53 μmol/kg, with no detectable effect on measured endpoints.
Reached brain levels of 1.5 μmol/kg, resulting in a significant 20% reduction in forebrain C99 and a significant 26% reduction in CSF Aβ40; no significant reduction in brain Aβ40 was observed.
分子量

557.81

Formula

C33H55N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NB-533 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NB-5331146544-18-4NB533NB 533Beta-secretaseCathepsinAmyloid-βBACEβ-Secretase β-amyloid peptideAβAbetatransgenic miceBACE-1CHO cellsAPPC99MDCK mdr1a cellsalzheimer’s diseaseamyloid precursor proteinAβ40cathepsin DInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
NB-533
目录号：
HY-182429
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z