NB-64

目录号: HY-137156 一键复制产品信息: Data Sheet 产品使用指南
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NB-64 是一种口服有效的 HIV-1 抑制剂。NB-64 有望用于 HIV 感染的研究。

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NB-64 Chemical Structure

CAS No. : 53242-68-5

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HIV HIV-1 HIV-2

生物活性
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参考文献

生物活性

NB-64 is an orally active HIV-1 inhibitor. NB-64 is promising for research of HIV infections^[1].

IC₅₀ & Target

HIV-1

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
MT2	CC₅₀	335.7 μM Compound: 1, NB-64	Cytotoxicity against human MT2 cells after 4 days using XTT assay Cytotoxicity against human MT2 cells after 4 days using XTT assay	[PMID: 22014749]
MT2	CC₅₀	335.72 μM Compound: A1, NB-64	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	CC₅₀	> 4000 μM Compound: 15ii, NB-64	Toxicity against human MT2 cells Toxicity against human MT2 cells	[PMID: 26116177]
MT2	EC₅₀	2.39 μM Compound: A1, NB-64	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]
MT2	EC₅₀	2.4 μM Compound: 1, NB-64	Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA Antiviral activity against HIV1 3B infected in human MT2 cells assessed as inhibition of p24 production after 4 days by ELISA	[PMID: 22014749]
MT2	EC₅₀	29.92 μM Compound: 15ii, NB-64	Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells Antiviral activity against HIV1 3B assessed as inhibition of virus mediated cell fusion between MT2 cells and H9/HIV1 3B cells	[PMID: 26116177]
U-87MG ATCC	CC₅₀	> 4000 μM Compound: 15ii, NB-64	Toxicity against human U87-T4-CXCR4 cells Toxicity against human U87-T4-CXCR4 cells	[PMID: 26116177]
U373-MAGI	CC₅₀	> 4000 μM Compound: 15ii, NB-64	Toxicity against human U373-MAGI-CXCR4-CEM cells Toxicity against human U373-MAGI-CXCR4-CEM cells	[PMID: 26116177]

分子量

221.64

Formula

C₁₁H₈ClNO₂

CAS 号

53242-68-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Jiang S, et al. N-substituted pyrrole derivatives as novel human immunodeficiency virus type 1 entry inhibitors that interfere with the gp41 six-helix bundle formation and block virus fusion. Antimicrob Agents Chemother. 2004 Nov;48(11):4349-59. [Content Brief]

NB-64 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NB-6453242-68-5NB64NB 64HIVHuman immunodeficiency virusHIV-1HIV infectionsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NB-64

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