2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Necroptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism
  4. NecroX-2

NecroX-2 是一种强效的非半胱天冬酶依赖性坏死 (necrosis) 抑制剂。NecroX-2 可通过清除 DPPH 自由基和过亚硝酸盐发挥抗氧化活性。NecroX-2 可抑制 t-BHP 诱导的线粒体 (mitochondrial) ROS/RNS 生成，并在体外对 t-BHP 和 Doxorubicin (HY-15142A) 诱导的细胞死亡起到保护作用。NecroX-2 可用于神经系统疾病的相关研究。

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NecroX-2

NecroX-2 Chemical Structure

CAS No. : 1120333-38-1

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NecroX-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NecroX-2 is a potent inhibitor of caspase-independent necrosis. NecroX-2 exhibits antioxidant activity by scavenging DPPH radicals and peroxynitrite. NecroX-2 inhibits t-BHP-induced mitochondrial ROS/RNS generation, and protects t-BHP and Doxorubicin (HY-15142A)-induced cell death in vitro. NecroX-2 can be used for research on neurological diseases[1][2].

体外研究
(In Vitro)

NecroX-2 在 DPPH 自由基清除实验中表现出体外抗氧化活性，其 IC50 为 17 μM；以及过氧亚硝基阴离子清除活性，IC50 为 0.9 μM[1]。
NecroX-2 (0.4-10 μM；2 h) 可抑制铜离子诱导的低密度脂蛋白 (LDL) 氧化[1]。
NecroX-2 (2 小时) 可强效抑制 t-BHP 诱导的 H9C2 细胞线粒体 ROS/RNS 生成，其 IC₂₅ < 0.1 μM[1]。
NecroX-2 (0.1-10 μM；预处理 30 min) 对 H9C2 细胞中 t-BHP 诱导的细胞死亡具有剂量依赖性的细胞保护作用[1]。
NecroX-2 (0.063-1.0 μM；预处理 30 min) 以剂量依赖方式保护原代大鼠肝细胞免受 Doxorubicin 诱导的细胞死亡，其 IC50 为 0.12 μM[1]。
NecroX-2 (0.3 μM；30 min) 可抑制镉暴露的 SH-SY5Y 和 PC12 神经细胞中不依赖半胱天冬酶的坏死[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NecroX-2 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: H9C2 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 30 min
Result: Showed a dose-dependent cytoprotective effect against t-BHP-induced cell death, as measured by LDH assay.

Cell Viability Assay[1]

Cell Line: primary rat hepatocytes
Concentration: 0.063, 0.125, 0.25, 0.5, 1.0 μM
Incubation Time: 30 min pretreat
Result: Displayed a dose-dependent cytoprotective effect against Doxorubicin-induced cell death at concentrations from 0.063 to 1.0 μM, with an IC50 of 0.12 μM, as measured by WST-1 assay.
分子量

516.68

Formula

C25H32N4O4S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NecroX-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NecroX-21120333-38-1NecroX2NecroX 2NecroptosisReactive Oxygen Species (ROS)Mitochondrial MetabolismSH-SY5Y cellslow-density lipoproteinmesothelioma cellsneuronal cellsmitochondrial reactive oxygen speciescaspase-independent nonapoptotic cell deathperoxynitritePC12 cellsInhibitorinhibitorinhibit

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