2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) DNA/RNA Synthesis Interleukin Related
  4. Neuroprotective agent 16

Neuroprotective agent 16 是一种可透过血脑屏障的神经保护剂。Neuroprotective agent 16 可清除 DPPH 和 ABTS 自由基，IC50 分别为 7.98 μM 和 5.50 μM。Neuroprotective agent 16 具有抗炎、抗氧化和减轻 DNA 损伤的活性。Neuroprotective agent 16 可用于缺血性脑卒中等疾病的研究。

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Neuroprotective agent 16

Neuroprotective agent 16 Chemical Structure

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Neuroprotective agent 16 相关抗体

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuroprotective agent 16 is a blood-brain barrier-permeable neuroprotective agent. Neuroprotective agent 16 effectively scavenges DPPH and ABTS radicals, with IC50 values of 7.98 μM and 5.50 μM, respectively. Neuroprotective agent 16 exhibits anti-inflammatory, antioxidant, and DNA damage-reducing activities. Neuroprotective agent 16 can be used in research on diseases such as ischemic stroke[1].

IC50 & Target[1]

IL-17

 

体外研究
(In Vitro)

Neuroprotective agent 16 (Compound B16) (0.1-10 μM；24 h) 可保护 SH-SY5Y 细胞免受 tBHP 和或 OGD/R 诱导的损伤[1]。
Neuroprotective agent 16 (1 μM；24 h) 可缓解 tBHP 诱导的 SH-SY5Y 细胞周期阻滞与 DNA 损伤，以及清除细胞中过量的 ROS 和维持细胞线粒体膜电位[1]。
Neuroprotective agent 16 (0.1-10 μM；24 h) 可以剂量依赖的方式抑制经 tBHP 处理的 BV2 小胶质细胞中 TNF-α 和 IL-17 的分泌 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroprotective agent 16 相关抗体:

Cell Viability AssayWestern Blot AnalysisCell Proliferation AssayApoptosis AnalysisCell Cytotoxicity AssayCell Cycle AnalysisRT-PCRCell Autophagy AssayImmunofluorescenceCell Differentiation AssayCell Invasion AssayCell Migration Assay Real Time qPCRELISA Assay[1]

Cell Line: SH-SY5Y cell treated tBHP and/or OGD/R
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 h
Result: Improved cell morphology
and increased cell survival rates.

Cell Cycle Analysis[1]

Cell Line: SH-SY5Y cells treated tBHP
Concentration: 1 μM
Incubation Time: 24 h
Result: Reversed tBHP-induced G2/M phase arrest: increased S-phase cells from 1.49% to 6.97% and decreased G2/M-phase cells from 28.35% to 18.15%.
Significantly reduced intracellular γ-H2AX expression (a marker of DNA double-strand breaks) induced by tBHP.

ELISA Assay[1]

Cell Line: BV2 microglial cells treated tBHP
Concentration: 0.1, 1 and 10 μM
Incubation Time: 24 h
Result: Caused a dose-dependent decrease in TNF-α and IL-17 expression levels in tBHP-stimulated BV2 cells.
药代动力学
(Parmacokinetics)
Species Dose Route T1/2 Tmax Cmax AUC0-t AUC0-∞ MRT0-∞
Mice[1] 10 mg/kg i.p. 20.6 h 0.08 h 30826.1 ng/mL 23999.8 ng·h/mL 34356.5 ng·h/mL 21.4 h
体内研究
(In Vivo)

Neuroprotective agent 16 (Compound B16) (5-10 mg/kg；腹腔注射；单次给药) 对 MCAO/R 小鼠具有神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, 7 weeks old, 25-35 g, MCAO/R modeling)[1]
Dosage: 5 mg/kg; 10 mg/kg
Administration: i.p.; single dose
Result: Reduced cerebral infarct volume significantly from 43.23% to 3.59% at 5 mg/kg.
Restored cerebral blood flow in the ischemic region, improved body weight recovery, and increased scores from balance beam, pole climbing, and corner tests.
Reduced perivascular white gaps and improved pyramidal cell morphology in hippocampal CA1 region and reduced neuronal edema/necrosis and preserved Nissl bodies. Significantly recovered Occludin and ZO-1 protein expression.
分子量

389.88

Formula

C20H24ClN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroprotective agent 16 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroprotective agent 16Neuroprotective agent16Neuroprotective agent-16Reactive Oxygen Species (ROS)DNA/RNA SynthesisInterleukin RelatedILSH-SY5Y cellsDPPHABTSmiceBV2 microglial cellsischemic strokeInhibitorinhibitorinhibit

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