2. Cell Cycle/DNA Damage Epigenetics Anti-infection
  3. HDAC Bacterial
  4. NHNB

NHNB 是一种选择性 HDAC8 抑制剂 (IC50 = 66.0 μM)，同时也是肽聚糖 N-乙酰氨基葡萄糖 (GlcNAc) 脱乙酰酶 (PGNGdacs) 抑制剂。NHNB 对 B. anthracis 和 B. cereus 具有抗菌和杀菌活性。NHNB 可用于急性髓系白血病、Bacillus anthracis 感染及 Bacillus cereus 感染的相关研究。

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NHNB

NHNB Chemical Structure

CAS No. : 106359-61-9

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NHNB 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NHNB is a selective HDAC8 inhibitor (IC50 = 66.0 μM) and Peptidoglycan N-acetylglucosamine (GlcNAc) deacetylases (PGNGdacs) inhibitor. NHNB shows antibacterial and bactericidal activity against B. anthracis and B. cereus. NHNB can be used for the research of acute myeloid leukemia, Bacillus anthracis infection, and Bacillus cereus infection[1][2].

IC50 & Target[1]

hHDAC8

66 μM (IC50)

体外研究
(In Vitro)

NHNB (Compound 4) 可抑制重组人源 HDAC8，其 IC50 为 66.0 μM[1]。
NHNB (0-5000 μM; 5 min ) 是纯化蜡样芽孢杆菌 (B. cereus) BC1974 肽聚糖脱乙酰酶的竞争性抑制剂，其 IC50 为 43.3 μM，Ki 为 8.7 μM[2]。
NHNB (0-5000 μM; 10 min) 是纯化蜡样芽孢杆菌 (B. cereus) BC1960 肽聚糖脱乙酰酶的竞争性抑制剂，其 IC50 为 132 μM，Ki 为 66.0 μM[2]。
NHNB (4 μg/mL; 16 h) 可诱导蜡样芽孢杆菌和炭疽芽孢杆菌产生更长的子代细胞链 [2]。
NHNB 对蜡样芽孢杆菌 ATCC 14579 和炭疽芽孢杆菌 7702的最低抑菌浓度 (MIC) 为 5.26–7.89 μg/mL，最低杀菌浓度 (MBC) 为 8.23 μg/mL[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NHNB 相关抗体:
分子量

263.29

Formula

C17H13NO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NHNB 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NHNB106359-61-9HDACBacterialHistone deacetylasesBacillus cereusHDAC6HDAC1BC1960HDAC8peptidoglycan deacetylaseBC1974peptidoglycan N-acetylglucosamine deacetylasesacute myeloid leukemiaBacillus anthracisInhibitorinhibitorinhibit

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