2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. NO-794

NO-794 是一种组胺 H2 受体 (histamine H2 receptor) 拮抗剂。NO-794 可抑制幽门结扎大鼠的胃酸分泌。NO-794 可用于消化性溃疡的研究。

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NO-794

NO-794 Chemical Structure

CAS No. : 105150-87-6

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NO-794 相关抗体

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NO-794 is a histamine H2 receptor antagonist. NO-794 inhibits gastric acid secretion in pylorus-ligated rats. NO-794 can be used for the research of peptic ulcers[1].

IC50 & Target[1]

H2 Receptor

 

体外研究
(In Vitro)

NO-794 (0-30 min) 是一种作用强劲、具有时间依赖性且不可逆的组胺 H2 受体拮抗剂，在分散的豚鼠胃黏膜细胞中发挥作用，其 -log KB 值为 8.4[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NO-794 相关抗体:
体内研究
(In Vivo)

NO-794 (0.5-2 mg/kg；皮内注射；单次给药) 可强效抑制幽门结扎大鼠的胃酸分泌，其 ED50 为 0.9 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 180-210 g, pylorus-ligated model)[1]
Dosage: 0.5 mg/kg; 1.0 mg/kg; 2 mg/kg
Administration: i.d.; single dose
Result: Reduced gastric acid output compared to controls at 0.5 mg/kg.
Significantly reduced gastric acid output by greater margins at 1.0 mg/kg and 2.0 mg/kg.
Achieved an ED50 value of 0.9 mg/kg for reduction of gastric acid secretion.
Demonstrated approximately 14 times more potency than ranitidine.
分子量

392.49

Formula

C23H28N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NO-794 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NO-794105150-87-6NO794NO 794Histamine Receptorhistamine H2 receptor antagonistpeptic ulcersWistarratInhibitorinhibitorinhibit

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HY-182643
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