2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis
  3. nAChR TNF Receptor
  4. NS-6740 hydrochloride

NS-6740 hydrochloride 是一种 α7 烟碱型乙酰胆碱受体 (α7 nAChR) 的部分激动剂，其 IC50 为 3 nM。NS-6740 hydrochloride 也是胆碱能抗炎通路的一种有效调节剂。NS-6740 hydrochloride 以不依赖于离子通道的方式改变 α7 的信号传导模式，从而降低突触功能。NS-6740 hydrochloride 可以诱导 α7 nAChR 的脱敏状态。NS-6740 hydrochloride 可以产生强烈的 nAChR 介导的电流。NS-6740 hydrochloride 可减少 LPS (HY-D1056) 诱导的小胶质细胞释放 TNF-α。NS-6740 hydrochloride 可用于神经炎症和神经性疼痛的研究。

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NS-6740 hydrochloride

NS-6740 hydrochloride Chemical Structure

CAS No. : 753499-14-8

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Other Forms of NS-6740 hydrochloride:

NS-6740 hydrochloride 相关抗体

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查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NS-6740 hydrochloride is a partial agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 hydrochloride also acts as a potent modulator of the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride alters the signaling pattern of α7 in an ion channel-independent manner, thereby reducing synaptic function. NS-6740 hydrochloride induces the desensitized state of α7 nAChR. NS-6740 hydrochloride generates robust nAChR-mediated currents. NS-6740 hydrochloride reduces LPS (HY-D1056)-induced TNF-α release from microglia. NS-6740 hydrochloride can be used in the research of neuroinflammation and neuropathic pain[1][2].

体外研究
(In Vitro)

NS-6740 (0.01-100 μM; 4.5 h) hydrochloride 可降 LPS 诱导的原代大鼠小胶质细胞富集培养物中 TNF-α 的释放，在 25 μM 浓度下可产生显著抑制作用，在 50 μM 和 100 μM 浓度下则可完全抑制[1]。
NS-6740 (5 μM; 60 s) hydrochloride 可诱导在 Xenopus laevis 卵母细胞中表达的人源 α7 nAChR 发生持续性脱敏，阻断其对 ACh 的反应，但不会影响受体对正变构调节剂 PNU-120596 (HY-12152) 的激活响应[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NS-6740 hydrochloride 相关抗体:
分子量

400.82

Formula

C19H20ClF3N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NS-6740 hydrochloride 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NS-6740753499-14-8NS6740NS 6740nAChRTNF ReceptorNicotinic acetylcholine receptorsTumor Necrosis Factor ReceptorTNFRacetylcholineGluR1+GluR2 AMPA-type glutamate receptorsdentate gyrusTNF-αcholinergic anti-inflammatory pathwayα2β2 nicotinic acetylcholine receptorsα7 nicotinic acetylcholine receptorlong-term potentiationhippocampal slicesmicrogliaInhibitorinhibitorinhibit

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产品名称：
NS-6740 hydrochloride
目录号：
HY-118646A
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