2. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease Others
  3. P-glycoprotein Cytochrome P450 Drug Isomer
  4. NSC 23925B

NSC 23925B 是一种 P-糖蛋白 (P-gp) 抑制剂，也是 NSC23925 (HY-19626) 生物活性最强的异构体，可逆转并预防癌细胞中由 P-糖蛋白介导的多药耐药性。NSC 23925B 对大多数 CYP450 酶的抑制很弱 (IC50 > 10 μM），对 CYP2B6 和 CYP2D6 显示出中度抑制活性，其 IC50 分别为 8.589 μM 和 1.407 μM。NSC 23925B 可用于多药耐药性癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

NSC 23925B

NSC 23925B Chemical Structure

CAS No. : 1369591-04-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

NSC 23925B 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSC 23925B is a P-glycoprotein (P-gp) inhibitor, as well as the most biologically active isomer of NSC23925 (HY-19626), which reverses and prevents P-glycoprotein-mediated multidrug resistance in cancer cells. NSC 23925B shows weak inhibition against most CYP450 enzymes (IC50 > 10 μM), and exhibits moderate inhibitory activity against CYP2B6 and CYP2D6 with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B can be used for the research of multidrug-resistant cancers[1].

体外研究
(In Vitro)

NSC 23925B 可强效逆转人乳腺癌和结肠癌多药耐药 (MDR) 细胞系中由 Pgp 介导的多药耐药性[1]。
NSC 23925B 抑制卵巢癌细胞和骨肉瘤细胞中由 Pgp 介导的抗癌药物耐药性的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC 23925B 相关抗体:
体内研究
(In Vivo)

NSC 23925B (2.50-93.75 mg/kg；腹腔注射；静脉注射；单次给药) 在雄性 BALB/c 小鼠中表现出良好的药代动力学特征，包括生物利用度高、血浆浓度 24 小时内可检测且毒性有限；其雄性小鼠的最大耐受剂量 (腹腔注射) 至少为 68.80 mg/kg，雌雄小鼠的最大耐受剂量 (静脉注射) 均为 24.70 mg/kg[1]。
NSC 23925B (2.50-47.20 mg/kg；腹腔注射；静脉注射；单次给药) 在雄性 Sprague-Dawley 大鼠中表现出良好的药代动力学特征，具有高生物利用度、24 小时内可检测到的血浆浓度，且毒性有限；雄性大鼠中的最大耐受剂量在腹腔注射时至少为 33.10 mg/kg，静脉注射时至少为 38.80 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

421.36

Formula

C22H26Cl2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC 23925B 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSC 23925B1369591-04-7P-glycoproteinCytochrome P450Drug IsomerP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243CYPsCYP2B6CYP3A4CYP1A2Sprague-Dawley ratscancer cellsCYP2D6multidrug resistanceBALB/c micecytochrome P450Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
NSC 23925B
目录号：
HY-117593
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z