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  4. NSC145366 monohydrochloride

NSC145366 monohydrochloride 是一种 Hsp90 C 端抑制剂。NSC145366 monohydrochloride 可直接与 Hsp90 C 端相互作用并抑制其伴侣活性。NSC145366 monohydrochloride 对酿酒酵母 cog7Δ、cog8Δ 菌株生长具有强抑制作用。

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NSC145366 monohydrochloride

NSC145366 monohydrochloride Chemical Structure

CAS No. : 1052515-37-3

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NSC145366 monohydrochloride 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

NSC145366 monohydrochloride (20-100 μM; 0-60 h) 可抑制 S. cerevisiae cog7Δ 和 cog8Δ 菌株的生长，诱导 ras2Δ 菌株产生选择性敏感性[1]。
NSC145366 monohydrochloride (500 μM; 2 h) 可在 MDA-MB-468 细胞裂解物中直接结合 Hsp90[1]。
NSC145366 monohydrochloride (10-40 μM; 60 min) 可剂量依赖性地抑制重组 Hsp90α C 端结构域的分子伴侣固有活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NSC145366 monohydrochloride 相关抗体:
分子量

635.36

Formula

C37H63ClN2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSC145366 monohydrochloride 相关分类

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Keywords:

NSC145366 monohydrochloride1052515-37-3HSPFungalHeat shock proteinsHsp90C-terminal domainMDA-MB-468Inhibitorinhibitorinhibit

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