2. Neuronal Signaling Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Cholinesterase (ChE) Monoamine Oxidase Amyloid-β Reactive Oxygen Species (ROS)
  4. NSS-18

NSS-18 是一种强效的、可逆性的 AChE 和 MAO-B 抑制剂，其 IC50 为 1.53 和 1.51 μM。NSS-18 可抑制 Aβ 自身聚集。NSS-18 抑制 Aβ 诱导的细胞内 ROS 生成。NSS-18 对 6-OHDA (HY-B1081) 诱导的神经毒性显示出中度的神经保护作用。NSS-18 能与 Cu²⁺、Fe³⁺、Zn²⁺ 等金属离子形成螯合物，其中与 Cu²⁺ 的螯合作用最强。NSS-18 可用于研究阿尔茨海默症。

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NSS-18

NSS-18 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

NSS-18 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC50 values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of ROS induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease[1].

IC50 & Target[1]

AChE

1.53 μM (IC50)

MAO-B

1.51 μM (IC50)

分子量

405.44

Formula

C24H23NO5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NSS-18 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NSS-18NSS18NSS 18Cholinesterase (ChE)Monoamine OxidaseAmyloid-βReactive Oxygen Species (ROS)MAOβ-amyloid peptideAβAbetaAlzheimer's diseaseMonoamine oxidase3-Hydroxy chromonesMultipotent drugsChromone derivativesMulti-target directed ligandsMAO-B inhibitorsAβ aggregationMolecular dockingMolecular dynamicsFluorescence propertiesInhibitorinhibitorinhibit

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目录号：
HY-180114
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