2. Immunology/Inflammation Metabolic Enzyme/Protease
  3. NTPDase Phosphodiesterase (PDE)
  4. NTPDase/NPP1-IN-1

NTPDase/NPP1-IN-1 是一种外核苷酸酶 (NTPDase) 和磷酸二酯酶-1 (NPP1) 抑制剂，对 h-NTPDase1、h-NTPDase2 和 h-NTPDase3、h-NPP1 的 IC50 分别为 0.28、0.92、0.82 和 0.73 μM。NTPDase/NPP1-IN-1 是一种膜相互作用剂，可定位于质膜并与癌细胞发生相互作用。NTPDase/NPP1-IN-1 可用于乳腺癌的研究。

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NTPDase/NPP1-IN-1

NTPDase/NPP1-IN-1 Chemical Structure

CAS No. : 2326978-03-2

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NTPDase/NPP1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 NTPDase 亚型特异性产品:

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NTPDase2

查看 Phosphodiesterase (PDE) 亚型特异性产品:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NTPDase/NPP1-IN-1 is an ectonucleotidase (NTPDase) and nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) inhibitor, with IC50 values of 0.28, 0.92, 0.82 and 0.73 μM against h-NTPDase1, h-NTPDase2, h-NTPDase3 and h-NPP1, respectively. NTPDase/NPP1-IN-1 is a membrane-interacting agent that localizes to the plasma membrane and interacts with cancer cells. NTPDase/NPP1-IN-1 can be used in the research of breast cancer[1].

体外研究
(In Vitro)

NTPDase/NPP1-IN-1 (Compound 4d) (10 μM; 24 h) 特异性定位于人肺癌 A549 细胞的质膜，并且具有适用于生物成像的稳定荧光特性[1]。
NTPDase/NPP1-IN-1 (0-100 μM; 24-72 h) 对人乳腺癌细胞 MCF-7 具有时间依赖性的抗增殖活性，处理 72 h 后细胞活力下降[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NTPDase/NPP1-IN-1 相关抗体:
分子量

284.26

Formula

C16H10F2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NTPDase/NPP1-IN-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NTPDase/NPP1-IN-12326978-03-2NTPDasePhosphodiesterase (PDE)Nucleoside triphosphate diphosphohydrolasesbreast cancerextracellular nucleotide metabolismNTPDase3A549 human lung carcinoma cellsh-NTPDase2plasma membraneNPP1h-NTPDase1lung cancerectonucleotidaseInhibitorinhibitorinhibit

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