1. 多肽产品
  2. 多肽及其衍生物
  3. 多肽药物递送
  4. 靶向肽
  5. Nuclear localizing sequence

Nuclear localizing sequence 是一种发挥诱导剂功能的肽序列,在哺乳动物细胞中具有膜渗透活性。Nuclear localizing sequence 可增强细胞摄取能力,并将偶联的钌 (II) 复合物导向细胞核,用于细胞核 DNA 成像。

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Nuclear localizing sequence

Nuclear localizing sequence Chemical Structure

CAS No. : 503474-42-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nuclear localizing sequence is a peptide sequence that functions as an inducer and exhibits membrane permeability in mammalian cells. Nuclear localizing sequence enhances cellular uptake and directs conjugated ruthenium (II) complexes to the nucleus for nuclear DNA imaging[1][2].

体外研究
(In Vitro)

Nuclear localizing sequence (Compound 12a) 可将偶联的 [Ru (bpy)2 (dppz)]2+ 复合物靶向细胞核,借助该复合物的“光开关”发射行为实现核 DNA 的选择性成像[1]
Nuclear localizing sequence 与带有高氯酸根抗衡离子的钌 (II) 联喹啉复合物偶联后,可在 CHO 和 HeLa 细胞中实现高效细胞摄取[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1282.60

Formula

C55H103N21O12S

CAS 号
Sequence

Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-NH2

Sequence Shortening

VQRKRQKLMP-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nuclear localizing sequence
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