1. Cell Cycle/DNA Damage Anti-infection
  2. DNA/RNA Synthesis Bacterial
  3. NusB-NusE interaction IN-1

NusB-NusE interaction IN-1 (compound 1) 是一种 NusB-NusE 蛋白-蛋白相互作用抑制剂和生长抑制剂,对枯草芽孢杆菌的 IC50 为 6.1 μM。NusB-NusE interaction IN-1 可抑制革兰氏阳性菌枯草芽孢杆菌的生长。NusB-NusE interaction IN-1 可抑制革兰氏阴性菌大肠杆菌的生长。

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NusB-NusE interaction IN-1

NusB-NusE interaction IN-1 Chemical Structure

CAS No. : 125966-81-6

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生物活性

NusB-NusE interaction IN-1 (compound 1) is a NusB-NusE protein-protein interaction inhibitor and growth inhibitor with a Bacillus subtilis IC50 of 6.1 μM.NusB-NusE interaction IN-1 inhibits growth of Gram-positive Bacillus subtilis.NusB-NusE interaction IN-1 inhibits growth of Gram-negative Escherichia coli[1].

体外研究
(In Vitro)

NusB-NusE interaction IN-1 (compound 1) (25 μM;37 °C 条件下处理 15 分钟,室温条件下处理 1 小时) 可强效抑制枯草芽孢杆菌 NusB 与 NusE 之间的蛋白-蛋白相互作用,其 IC50 为 6.1 μM,在 25 μM 浓度下抑制率达 88%[1]
NusB-NusE interaction IN-1 (compound 1) (200 μM; 16 h at 37 °C) 可在 200 μM 浓度下中度抑制枯草芽孢杆菌 (抑制率 9%) 和大肠杆菌 DH5α(抑制率 21%) 的生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

564.61

Formula

C28H28N4O7S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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NusB-NusE interaction IN-1
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HY-123722
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