2. Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. FGFR IFNAR Interleukin Related
  4. OM-RCA-01

OM-RCA-01 是一种抗 FGFR1 单克隆抗体，其与人源 FGFR1 的 Kd 为 1.59 nM。OM-RCA-01 可抑制 FGFR1 的磷酸化，阻断 FGF 介导的信号通路，并抑制下游肿瘤细胞的增殖。OM-RCA-01 可延缓表达 FGFR1 的肺癌和肾癌异种移植模型中的肿瘤生长。OM-RCA-01 与 Nivolumab 联用时，可增强 IFN-γ 和 IL-2 的释放。OM-RCA-01 可用于肺癌、肾细胞癌的研究。

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OM-RCA-01

OM-RCA-01 Chemical Structure

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Customer Review

OM-RCA-01 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OM-RCA-01 is an anti-FGFR1 monoclonal antibody with a Kd of 1.59 nM for human FGFR1. OM-RCA-01 inhibits the phosphorylation of FGFR1, blocks FGF-mediated signaling pathways, and suppresses the proliferation of downstream tumor cells. OM-RCA-01 delays tumor growth in lung cancer and renal cancer xenograft models expressing FGFR1. When combined with Nivolumab, OM-RCA-01 enhances the release of IFN-γ and IL-2. OM-RCA-01 is applicable for the research of lung cancer and renal cell carcinoma[1].

反应种属

Human
体外研究
(In Vitro)

OM-RCA-01 以高亲和力结合 FGFR1 (Kd = 1.59 nM)，并抑制其体外激酶活性[1]。
OM-RCA-01 (1-100 μg/mL, 3 h) 可强效抑制高表达 FGFR1 的人肺癌细胞系 A549 中 FGFR1 的磷酸化及细胞增殖 (GI50 = 9.69 μg/mL)，但对低表达 FGFR1 的人黑色素瘤细胞系 Mel Kor 无显著影响[1]。
OM-RCA-01 (0.5-10 nmol/l; 5 days) 与 Nivolumab (HY-P9903) 联用时，可在人同种异体 MLR 实验中增强 Nivolumab 诱导的 IFN-γ 释放及 T 细胞增殖，但单独使用时作用极小[1]。
OM-RCA-01 (1 μg/mL; 4 days) 可在 Staphylococcal enterotoxin B (SEB) (HY-P1900) 刺激的人外周血单个核细胞 (PBMCs) 中，将 Nivolumab 诱导的 IL-2 分泌量提升 29%-74%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OM-RCA-01 相关抗体:

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 1-100μg/mL
Incubation Time: 3 h
Result: Resulted in a dose-dependent
suppression of FGFR1 phosphorylation.
药代动力学
(Parmacokinetics)
Species Dose Route C0 T1/2 Vd CL AUC0-t AUC0-∞ MRT
Rat[1] 10 mg/kg i.v. 186 ng/mL 121 h 532 L 3.05 L/h 10665 ng·h/mL 32818 ng·h/mL 34 h
Rat[1] 30 mg/kg i.v. 177 ng/mL 136 h 2533 L 12.88 L/h 14237 ng·h/mL 46602 ng·h/mL 34 h
Rat[1] 100 mg/kg i.v. 245 ng/mL 234 h 7569 L 22.44 L/h 16383 ng·h/mL 89131 ng·h/mL 35 h
体内研究
(In Vivo)

OM-RCA-01 (30 mg/kg; i.v.; twice weekly) 可使 A549 肺癌异种移植模型的中位肿瘤体积产生具有统计学意义的两倍降低，并延缓肿瘤生长，联合 Pembrolizumab (HY-P9902) 可实现 89%的肿瘤生长抑制[1]。
OM-RCA-01 (30 mg/kg; every 3 days) 可在 癌症相关成纤维细胞 (CAF) 阳性肾癌队列中实现 96%的肿瘤生长延迟，在 CAF 阴性肾癌队列中实现 75%的肿瘤生长延迟，同时可提升 IFN-γ 和 IL-2 细胞因子水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCr nu/nu mice (female、6-12 weeks)[1]
Dosage: 30 mg/kg
Administration: i.v.; twice weekly
Result: Resulted in significant suppression of tumor growth.
Reduced median tumor volume Pembrolizumab alone.
Caused tumor growth to plateau with minimal growth from day 16 onwards.
Resulted in no deaths or body weight loss in the combination group.
Animal Model: Charles River mice[1]
Dosage: 30 mg/kg
Administration: every 3 days
Result: Achieved 96% tumor growth delay (TGD) in CAF-positive cohorts and 75% TGD in CAF-negative cohorts, both statistically significant.
Increased IFN-γ release by 43% and IL-2 secretion by 65% compared to the control IgG group.
基因 ID

2260  [NCBI]

Accession
靶点

FGFR1/CD331
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OM-RCA-01 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OM-RCA-01FGFRIFNARInterleukin RelatedFibroblast growth factor receptorInterferon-α/β receptorInterferon-alpha/beta receptor ILanti-FGFR1 monoclonal antibodyA549 cellsNCr nu/nu miceCharles River micelung cancerrenal cell carcinoma
Inhibitorinhibitorinhibit

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目录号：
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