2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. ADC Antibody FAP
  4. OMTX005

OMTX005 (OMTX705 antibody) 是一种人源化抗 FAP IgG1 单克隆抗体，可特异性结合人 (EC50: 0.33 nM) /鼠源 (EC50: 为 0.14 nM) FAP 蛋白及 FAP 阳性的细胞。OMTX005 单独使用无细胞毒性，无法诱导相关细胞的 caspase 3/7 活性升高。OMTX005 可用于合成 ADC 分子 OMTX705，用于肿瘤的研究。

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OMTX005

OMTX005 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

OMTX005 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

OMTX005 (OMTX705 antibody) is a humanized anti-FAP IgG1 monoclonal antibody that specifically binds to human (EC50: 0.33 nM)/mouse (EC50: 0.14 nM) FAP proteins and FAP-positive cells. OMTX005 exhibits no cytotoxicity when used alone and fails to induce an increase in caspase 3/7 activity in relevant cells. OMTX005 can be used to synthesize the ADC molecule OMTX705 for tumor research[1].

反应种属

Human
体外研究
(In Vitro)

OMTX005 可特异性结合表达 FAP 的 HT1080-FAP 细胞和原代 CAF07 细胞，EC50 值分别为 76 pM 和 130 nM[1]。
OMTX005 (5 days) 不会降低 HT1080-WT、HT1080-FAP 或原代 CAF07 细胞的存活率[1]。
OMTX005 (400 nmol/L; 0-48 h) 不会在 HT1080-WT、HT1080-FAP 或原代 CAF07 细胞中诱导 caspase 3/7 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

OMTX005 相关抗体:

Cell Viability Assay[1]

Cell Line: HT1080-WT, HT1080-FAP, primary CAF07 cells
Concentration: up to 400 nmol/L
Incubation Time: 5 days
Result: Did not exhibit cytotoxic activity in any of the cell lines tested.
基因 ID

2191  [NCBI]

Accession
靶点

FAP
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

OMTX005 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OMTX005OMTX705 antibodyOMTX 005OMTX-005ADC AntibodyFAPFibroblast activation proteinpancreatic cancertriple-negative breast cancernon-small cell lung cancerhumancaspase 3/7murineintratumoral stromal cellsfibroblast-activating proteinPDX modelhumanized PDX modelsInhibitorinhibitorinhibit

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目录号：
HY-P991995
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