2. Others Metabolic Enzyme/Protease Anti-infection
  3. Reference Standards Cathepsin SARS-CoV
  4. ONO-5334 (Standard)

ONO-5334 (Standard) 是 ONO-5334 (HY-108044) 的分析标准品。本产品用于研究及分析应用。ONO-5334 是一种强效、选择性和口服活性的组织蛋白酶 K (cathepsin K) 抑制剂，对人、兔和大鼠组织蛋白酶 K 的作用值分别为 0.10 nM、0.049 nM 和 0.85 nM。ONO-5334 是一种有效的抗 SAR-COV-2 病毒活性的抗病毒化合物，其 EC50 值为 500 nM。ONO-5334 有潜力用于骨质疏松症以及 COVID-19 的相关研究。

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ONO-5334 (Standard)

ONO-5334 (Standard) Chemical Structure

CAS No. : 868273-90-9

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ONO-5334 (Standard) 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ONO-5334 (Standard) is the analytical standard of ONO-5334 (HY-108044). This product is intended for research and analytical applications. ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease[1].

IC50 & Target

Ki: 0.10 nM (human cathepsin K)
Ki: 0.049 nM (rabbit cathepsin K)
Ki: 0.85 nM (rat cathepsin K)[1]
分子量

438.58

Formula

C21H34N4O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ONO-5334 (Standard) 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ONO-5334 (Standard)868273-90-9Reference StandardsCathepsinSARS-CoVSARS coronaviruspostmenopausalosteoporosisosteoclastPBMCsbonemineraldensityBMDSAR-COV-2COVID-19Inhibitorinhibitorinhibit

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