2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Org 214444-0

Org 214444-0 是一种具有口服活性的纳摩尔级强效且选择性的 FSHR 激动剂，对人和大鼠的 EC50 为 2.0 和 1.2 nM (CHO 细胞中测定)。Org 214444-0 可在体外激活人颗粒细胞、在体内支持大鼠卵泡发育并诱导排卵。Org 214444-0 可用于不孕症的研究。

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Org 214444-0

Org 214444-0 Chemical Structure

CAS No. : 914093-78-0

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Org 214444-0 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Org 214444-0 is an orally active, nanomolar-potent and selective FSHR agonist, with EC50 values of 2.0 nM and 1.2 nM in human and rat (measured in CHO cells). Org 214444-0 activates human granulosa cells in vitro, supports rat follicular development and induces ovulation in vivo. Org 214444-0 can be used for the research of infertility[1].

体外研究
(In Vitro)

Org 214444-0 (1 h) 可刺激表达人 FSHR 的 CHO 细胞产生 cAMP，其 EC50 为 5 nM[1]。
Org 214444-0 (2 h) 可诱导 U2OS 细胞中带有 EGFP 标签的大鼠 FSHR 发生内化，其 EC50 为 97 nM[1]。
Org 214444-0 (1 nM-10 mM; 48 h) 可刺激人颗粒细胞产生雌二醇，其 EC50 约为 8.3 nM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Org 214444-0 相关抗体:
体内研究
(In Vivo)

Org 214444-0 (0.1-1.0 mg/kg；皮下注射/口服；每日 2 次 / 每 4 小时 1 次；动情周期至动情前期) 可剂量依赖性地支持雌性大鼠的卵泡期并诱导排卵[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orga rats (mature female)[1]
Dosage: 0.1 mg/kg; 0.25 mg/kg; 0.5 mg/kg; 1.0 mg/kg (s.c.); 1.0 mg/kg (p.o.)
Administration: s.c.; twice daily on met-estrus and diestrus, once on proestrus morning; p.o.; every 4 hours
Result: Caused a dose-dependent increase in the number of ovulated ova per rat.
分子量

664.56

Formula

C30H32BrF2N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Org 214444-0 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org 214444-0914093-78-0Estrogen Receptor/ERRmature female ratsFSHRhuman granulosa cellscAMPCHO cellsLHRTSHRphospholipase CU2OS cellsadenylyl cyclaseInhibitorinhibitorinhibit

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Org 214444-0
目录号：
HY-182705
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