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  3. Drug Intermediate
  4. P-SCN-Bn-NOTA

P-SCN-Bn-NOTA 是一种金属螯合剂和分子成像探针前体，可用 Ga-68 放射性标记。P-SCN-Bn-NOTA 可与 CD70 特异性分子 B3、B6、ABDB3 和 ABDB6 偶联，形成 NOTA 标记的衍生物。P-SCN-Bn-NOTA 可用于在 NCG 小鼠 PDX 模型中对表达 CD70 的肿瘤进行临床前 PET/CT 成像。P-SCN-Bn-NOTA 可用于 CD70 阳性肿瘤的相关研究。

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P-SCN-Bn-NOTA

P-SCN-Bn-NOTA Chemical Structure

CAS No. : 147597-66-8

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25 mg ￥3840
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P-SCN-Bn-NOTA 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P-SCN-Bn-NOTA is a metal chelator and molecular imaging probe precursor that allows radiolabeling with Ga-68. P-SCN-Bn-NOTA can be conjugated to CD70-specific molecules B3, B6, ABDB3 and ABDB6 to form NOTA-labeled derivatives. P-SCN-Bn-NOTA is applicable for preclinical PET/CT imaging of CD70-expressing tumors in NCG mouse PDX models. P-SCN-Bn-NOTA can be used in studies related to CD70-positive tumors[1].

体内研究
(In Vivo)

p-SCN-Bn-NOTA (每只小鼠 3.7-7.4 MBq) 标记合成的放射性偶联物在 NCG 小鼠的 CD70 阳性 PDX 肿瘤中表现出选择性摄取，肿瘤摄取值根据偶联物和时间点的不同在 4 %ID/g 至 11 %ID/g 之间变化，且肾脏中的正常组织摄取量最高[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

450.51

Formula

C20H26N4O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P-SCN-Bn-NOTA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P-SCN-Bn-NOTA147597-66-8Drug IntermediateDrug IintermediateCD70anti-CD70 nanobodieskidneysgallium-68PDX modelsCD70-expressing tumorsNCG mouseradiometal chelationCD70-positive tumorsPET/CT imagingInhibitorinhibitorinhibit

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