2. 疾病领域
  3. 神经系统疾病
  4. 神经退行性疾病
  5. 帕金森病
  6. P7C3-S243

P7C3-S243 是一种可穿透血脑屏障的 P7C3 类神经保护剂。P7C3-S243 可通过激活代谢酶烟酰胺磷酸核糖转移酶来增强烟酰胺腺嘌呤二核苷酸的合成。P7C3-S243 在帕金森病小鼠模型中表现出强效的神经保护功效。P7C3-S243 可用于帕金森病的研究。

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P7C3-S243

P7C3-S243 Chemical Structure

CAS No. : 1421622-85-6

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P7C3-S243 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease[1].

体内研究
(In Vivo)

P7C3-S243 (10 mg/kg/天；腹腔注射；每日给药；诱导前 3 天预给药及诱导后 7 天连续给药) 可在帕金森病大鼠模型中拮抗 6-OHDA 诱导的多巴胺能神经元死亡，维持纹状体多巴胺及其代谢物水平，并恢复正常运动行为[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Long Evans (adult male, 250-300 g, unilateral stereotactic injection of 6-OHDA into right median forebrain bundle)[1]
Dosage: 10 mg/kg/day
Administration: intraperitoneal injection; daily; 7 days (with 3 days of pretreatment before 6-OHDA injection)
Result: Restored rearing ability, spontaneous locomotor activity, and reduced amphetamine-induced ipsiversive circling.
Increased survival of tyrosine hydroxylase-positive neurons in the ipsilateral substantia nigra pars.
Preserved tyrosine hydroxylase and NeuN colocalization in substantia nigra pars compacta neurons, with survival levels approximating sham-injured rats.
Significantly restored levels of striatal dopamine, DOPAC, and homovanillic acid toward normal sham-injured levels; no effect on striatal serotonin levels.
分子量

507.19

Formula

C21H18Br2FN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

P7C3-S243 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

P7C3-S2431421622-85-6Others6-OHDAblood-brain barriernicotinamide adenine dinucleotidemitochondrial integritydopaminergic neuronsneuronal survivalhippocampal neuronsnicotinamide phosphoribosyltransferaseParkinson's diseaseInhibitorinhibitorinhibit

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