2. Metabolic Enzyme/Protease Cytoskeleton Cell Cycle/DNA Damage
  3. Liposome Microtubule/Tubulin
  4. Paclitaxel liposome

Paclitaxel liposome  (Synonyms: 紫杉醇脂质体; Liposomal paclitaxel)

目录号: HY-185373
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Paclitaxel liposome 是一种被脂质体包封的 Paclitaxel (HY-B0015)。Paclitaxel 是一种天然抗肿瘤药，可稳定微管蛋白 (tubulin) 的聚合。Paclitaxel liposome 具有急性毒性降低、紫杉醇循环半衰期延长以及肿瘤部位蓄积增强的特点。Paclitaxel liposome 可用于乳腺癌和局部晚期食管鳞状细胞癌的相关研究。

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Paclitaxel liposome

Paclitaxel liposome Chemical Structure

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Paclitaxel liposome 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Paclitaxel liposome is a liposome-encapsulated form of Paclitaxel (HY-B0015). Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel liposome is characterized by reduced acute toxicity, prolonged circulating half-life of paclitaxel, and enhanced accumulation at tumor sites. Paclitaxel liposome can be used in research related to breast cancer and locally advanced esophageal squamous cell carcinoma[1][2].

体外研究
(In Vitro)

Paclitaxel liposome (0.1-5000 ng/mL; 24-72 h) 对人乳腺癌 MCF-7 细胞具有强效、时间和浓度依赖性的细胞毒性，处理 72 h 后的 IC50 为 11.54 ng/mL[1]。
Paclitaxel liposome (5 μg/mL RhB; 1-4 h, tracked via rhodamine B labeling) 可被人乳腺癌 MCF-7 细胞摄取，其摄取效率低于靶向长效紫杉醇脂质体[1]。
Paclitaxel liposome (0-48 h, stored at 4°C or room temperature) 具有均一的粒径、负表面电荷、高包封率，且在 4℃条件下储存长达 48 h 时稳定性良好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Paclitaxel liposome 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 0.1-5000 ng/mL
Incubation Time: 24 h; 48 h; 72 h
Result: Showed concentration- and time-dependent inhibitory effects on MCF-7 cells.
Failed to achieve an IC50 after 24 h of treatment.
Reached an IC50 of 2095 ng/mL after 48 h of treatment.
Reached an IC50 of 11 ng/mL after 72 h of treatment.
体内研究
(In Vivo)

Paclitaxel liposome (5 mg/kg；静脉注射；每 2 天 1 次；连续给药 4 次) 可抑制裸鼠体内 MCF-7 乳腺癌肿瘤的生长，在治疗启动后第 34 天将平均肿瘤体积降至 1700 mm3，同时可支持裸鼠体重逐步增长[1]。
Paclitaxel liposome (10 mg/kg；静脉注射；单剂量) 可适度延长紫杉醇在健康 ICR 小鼠体内的循环时间，其消除半衰期为 2.26 h，生物利用度较游离紫杉醇高 1.38 倍[1]。
普通紫杉醇脂质体 (L-PTX)(80-200 mg/kg；静脉注射；单次给药) 可降低健康 ICR 小鼠的急性毒性，其 LD50 为 134.46 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (female, 16-18 g, inoculated with MCF-7 human breast cancer cells)[1]
Dosage: 5 mg/kg (based on paclitaxel content)
Administration: i.v.; once every 2 days; 4 consecutive administrations
Result: Reached mean tumor volume of 1000 mm3 after 18 days of administration.
Reached mean tumor volume of 1700 mm3 after 34 days of administration.
Showed gradual increase in body weight throughout the study period.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Paclitaxel liposome 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paclitaxel liposomeLiposomal paclitaxelLiposomeMicrotubule/Tubulincaveolin-dependent endocytosisclathrin-dependent endocytosisbreast cancerlocally advanced esophageal squamous cell carcinomaMCF-7 cellsnude miceestrogen receptorICR micemacropinocytosisInhibitorinhibitorinhibit

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