2. Cell Cycle/DNA Damage Cytoskeleton Membrane Transporter/Ion Channel
  3. PAK Potassium Channel
  4. PAK1-IN-3

PAK1-IN-3 是一种 PAK1 抑制剂，IC50 为 10 nM，对 PAK2 的 IC50 为 20 nM，对 hERG 钾通道的 IC50 为 1079 nM。PAK1-IN-3 可通过定位正确的叔胺与 PAK1 中的 Asp106 形成盐桥。PAK1-IN-3 可抑制 PAK2 与 hERG 钾通道。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PAK1-IN-3

PAK1-IN-3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PAK1-IN-3 相关抗体

Top Publications Citing Use of Products

查看 PAK 亚型特异性产品:

查看所有亚型
PAK1 PAK2 PAK3 PAK4 PAK5 PAK6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PAK1-IN-3 is a PAK1 inhibitor with an IC50 of 10 nM, an IC50 of 20 nM against PAK2, and an IC50 of 1079 nM against hERG potassium channels. PAK1-IN-3 forms a salt bridge with Asp106 in PAK1 via a properly positioned tertiary amine. PAK1-IN-3 inhibits PAK2 and hERG potassium channels[1].

IC50 & Target[1]

PAK1

10 nM (IC50)

PAK2

20 nM (IC50)

体外研究
(In Vitro)

PAK1-IN-3 (Compound 12) 具有 3.02 的 logD7.4，在 PBS pH 7.4 中溶解度中等，血浆蛋白结合率高，在人肝细胞中具有类母体代谢稳定性，在 MDCKII 细胞中的外排率为 0.7，在 Caco-2 细胞中的外排率为 2.9[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PAK1-IN-3 相关抗体:
分子量

535.04

Formula

C27H31ClN8O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PAK1-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PAK1-IN-3PAKPotassium Channelp21 activated kinasesKcsAPAK4Caco-2 cellshuman hepatocytesPAK2human liver microsomesepithelial cell linesMDCKII cellsAsp106PAK1hERG potassium channelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PAK1-IN-3
目录号：
HY-182357
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z