2. Anti-infection Cell Cycle/DNA Damage
  3. Parasite DNA Alkylator/Crosslinker Bacterial
  4. Parthenin

Parthenin 是一种存在于 Parthenium hysterophorus L. 中的伪愈创木内酯型倍半萜内酯。Parthenin 可诱导人外周血淋巴细胞产生染色体畸变，主要为染色单体断裂。Parthenin 对 Salmonella typhimurium 和 Escherichia coli 菌株具有毒性，在存在代谢活化系统 (S9) 的情况下毒性降低。Parthenin 可作为斜纹夜蛾 (Spodoptera litura) 六龄幼虫的取食拒食剂。Parthenin 对四纹豆象 (Callosobruchus maculatus) 成虫具有杀虫活性。Parthenin 可抑制决明 (Cassia tora) 的种子萌发和幼苗生长。Parthenin 对南方根结线虫 (Meloidogyne incognita) 二龄幼虫具有杀线虫活性。Parthenin 可用于癌症、疟疾、阿米巴病、炎症性疾病和细菌感染的相关研究。

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Parthenin

Parthenin Chemical Structure

CAS No. : 508-59-8

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规格 价格 是否有货 数量
1 mg ￥5535
1 - 2 周
5 mg 询价 1 - 2 周
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Parthenin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Parthenin is a pseudoguaianolide-type sesquiterpene lactone present in Parthenium hysterophorus L. Parthenin induces chromosomal aberrations, mainly chromatid breaks, in human peripheral blood lymphocytes. Parthenin exhibits toxicity against Salmonella typhimurium and Escherichia coli strains, with reduced toxicity in the presence of a metabolic activation system (S9). Parthenin acts as an antifeedant against the 6th instar larvae of the tobacco cutworm (Spodoptera litura). Parthenin shows insecticidal activity against adult cowpea weevils (Callosobruchus maculatus). Parthenin inhibits seed germination and seedling growth of sicklepod (Cassia tora). Parthenin possesses nematicidal activity against the 2nd instar larvae of the southern root-knot nematode (Meloidogyne incognita). Parthenin serves as a research agent for studies related to cancer, malaria, amoebiasis, inflammatory diseases, and bacterial infections[1][2][3].

体外研究
(In Vitro)

Parthenin (0.19-19.06 μmole per plate) 对鼠伤寒沙门氏菌 Salmonella typhimurium 菌株 TA 1535、TA 1537、TA 98 和 TA 100 无致突变性，但在 0.19 和 0.49 μmole per plate 条件下可使菌株 TA 102 产生微弱、轻微的回复突变反应[1]。
Parthenin (10-60 μM; 17 h) 可在 10、20、40 和 60 μM 浓度下诱导人外周血淋巴细胞产生剂量依赖性染色体畸变，主要为染色单体断裂；在 40 μM 浓度下，其诱导的多倍体中期细胞数量呈临界显著性升高[1]。
Parthenin (100-1000 mg/L; 24-72 h) 对南方根结线虫 (Meloidogyne incognita) 的 II 龄幼虫 (J2) 在体外表现出中等杀线虫活性，暴露 48 h 后的 LC50 为 862 mg/L，暴露 72 h 后的 LC50 为 512 mg/L[2]。
Parthenin 对多重耐药恶性疟原虫表现出显著的抗疟活性，对青蒿素耐药的疟原虫也具有潜在应用价值[3]。
Parthenin 对溶组织内阿米巴具有杀阿米巴活性[3]。
Parthenin 可通过降低促炎细胞因子 TNF-α、IL-1β 和 IL-6 的表达，在小鼠中性粒细胞中发挥抗炎活性[3]。
Parthenin 对 Plutella xylostella、Aphis craccivora 和 Tribolium confusum 具有杀虫活性，且不同物种间的效力存在差异[3]。
Parthenin 可通过抑制孢子囊萌发、游动孢子活性及菌丝生长，对多种植物病原真菌表现出杀真菌活性[3]。
Parthenin (1 μg/mL; 24 h) 对培养的牛肾细胞具有细胞毒性，可将 RNA、DNA 和蛋白质的合成抑制近 50%[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Parthenin 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: Human peripheral blood lymphocytes
Concentration: 1, 5, 10, 20, 40, 60, 80 μM
Incubation Time: 20 h
Result: Induced significant increases in pycnosis and karyorrhexis.
Induced a significant increase in micronuclei.
Had an estimated minimal positive dose (MPD) for chromosomal aberrations of 27 μM, where 9% of cells showed significant nuclear morphological alterations.
体内研究
(In Vivo)

Parthenin (4-31 mg/kg；腹腔注射；单次给药) 在给药后 48 小时，当剂量为 31 mg/kg 时，可使雄性和雌性瑞士白化小鼠的微核网织红细胞频率显著升高，而低剂量或给药后 72 小时则无显著影响[1]。
Parthenin (对叶圆片进行局部施用) 对斜纹夜蛾 (Spodoptera litura) 六龄幼虫表现出中等水平的拒食活性；在双选试验中，其 ED50 为 287 mg/L，在 10000 mg/L 浓度下拒食率达 99%[2]。
Parthenin (25-1000 mg/L; 向培养皿表面局部施用) 对 Callosobruchus maculatus 成虫仅表现出极低的杀虫活性，暴露 72 小时后的 LC50 为 568 mg/L[2]。
Parthenin (100-3000 mg/L; 浸种) 是决明 (Cassia tora)种子萌发和幼苗生长的抑制剂，其 ID50 值分别为 364 mg/L (萌发)、738 mg/L (胚轴长度) 和 427 mg/L (胚根长度)[2]。
Parthenin 对小菜蛾表现出中等驱避活性 (LC50 = 1709.42 mg/L)，对蚜虫表现出高杀虫活性 (LC50 = 947.87 mg/L)[3]。
Parthenin 对储粮害虫具有杀虫活性，对根结线虫具有杀线虫活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss albino mice (both sexes, 20-25 g)[1]
Dosage: 4 mg/kg; 8 mg/kg; 16 mg/kg; 31 mg/kg
Administration: i.p.; single dose
Result: Induced a micronucleated reticulocyte frequency of 1.70 per 1000 reticulocytes in male mice at 31 mg/kg, 48 hours post-administration.
Induced a micronucleated reticulocyte frequency of 1.80 per 1000 reticulocytes in female mice at 31 mg/kg, 48 hours post-administration.
Caused one death in the female 31 mg/kg group at the 72-hour sampling time point.
Showed no significant increase in micronucleated reticulocyte frequency at 4, 8, or 16 mg/kg, or at any dose at 72 hours post-administration.
Produced no changes in reticulocyte proportion across any dose or time point.
分子量

262.30

Formula

C15H18O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Parthenin 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Parthenin508-59-8ParasiteDNA Alkylator/CrosslinkerBacterialPlasmodium falciparumSpodoptera liturahuman peripheral blood lymphocytesSalmonella typhimuriumCallosobruchus maculatusCassia toraEscherichia coliSwiss albino miceMeloidogyne incognitaEntamoeba histolyticaInhibitorinhibitorinhibit

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