2. Others Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Fluorescent Dye Reactive Oxygen Species (ROS)
  4. PCL-2

PCL-2 是一种响应活性氧的荧光探针，对过氧化氢以外的生物相关活性氧几乎无响应。PCL-2 可与过氧化氢反应释放 6-羟基-2-氰基苯并噻唑。PCL-2 可用于 in vitro 及急性炎症小鼠模型中过氧化氢的化学选择性成像。PCL-2 可用于急性炎症相关研究。

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PCL-2

PCL-2 Chemical Structure

CAS No. : 1421277-81-7

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PCL-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PCL-2 is a reactive oxygen species-responsive fluorescent probe that shows almost no response to biologically relevant reactive oxygen species other than hydrogen peroxide. PCL-2 reacts with hydrogen peroxide to release 6-hydroxy-2-cyanobenzothiazole. PCL-2 can be used for chemoselective imaging of hydrogen peroxide in in vitro models and acute inflammation mouse models. PCL-2 is applicable to studies related to acute inflammation[1].

体外研究
(In Vitro)

PCL-2 (5 μM; 5, 20, 40, or 60 min) 在无细胞体系中可选择性地使响应 H2O2 的生物发光信号增强约 50 倍，但对其他具有生物学相关性的 ROS 无此作用[1]。
PCL-2 (5 μM; 60 min) 可在无细胞体系中对 1-100 μM H2O2 产生线性增强的生物发光信号[1]。
PCL-2 (25 μM; 2 h) 可在 PC3M-luc 细胞中对 0-100 μM H2O2 产生呈线性增长且具有统计学显著性的生物发光信号[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PCL-2 相关抗体:
体内研究
(In Vivo)

PCL-2 (0.05 μmol；腹腔注射) 可在健康 FVB-luc+小鼠中响应外源性过氧化氢，产生剂量依赖性的、最高达 10 倍的生物发光激活信号，该信号可被过氧化氢清除剂抑制[1]。
PCL-2 (0.05 μmol；腹腔注射) 可检测到雌性 FVB-luc+小鼠脂多糖诱导的急性炎症过程中，内源性过氧化氢 (H2O2) 水平升高约 3.7 倍，而经 apocynin 处理后信号降低 55%[1]。
PCL-2 (0.05 μmol; 腹腔注射)，与 IETDC 联合使用时，可在脂多糖诱导的雌性 FVB-luc+小鼠急性炎症过程中，检测到内源性过氧化氢与 caspase 8 活性同时升高约 2.7 倍；而经抗坏血酸与 caspase 抑制剂联合处理后，信号降低 30%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FVB-luc+ (FVB-Tg(CAG-luc,-GFP)L2G85Chco/J) (female, 2-5 months)[1]
Dosage: 0.05 μmol (co-administered with 0.05 μmol D-cysteine)
Administration: intraperitoneal injection
Result: Produced a ~3.7-fold increase in total photon flux in lipopolysaccharide-challenged mice compared to saline-treated control mice.
Reduced this signal by ~55% when co-administered with apocynin relative to signal from lipopolysaccharide alone.
Animal Model: FVB-luc+ (FVB-Tg(CAG-luc,-GFP)L2G85Chco/J) (female, 2-5 months)[1]
Dosage: 0.05 μmol (co-administered with 0.05 μmol IETDC)
Administration: intraperitoneal injection
Result: Produced a ~2.7-fold increase in total photon flux in lipopolysaccharide-challenged mice compared to saline-treated control mice.
Reduced this signal by ~30% when co-administered with ascorbic acid and z-VD(OMe)-OPh relative to signal from lipopolysaccharide alone.
分子量

310.14

Formula

C15H11BN2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PCL-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PCL-21421277-81-7PCL2PCL 2Fluorescent DyeReactive Oxygen Species (ROS)reactive oxygen speciescaspase 8hydrogen peroxideFVB-luc+ micelipopolysaccharide-induced acute inflammationapocyninascorbic acidmurine models of acute inflammation6-hydroxy-2-cyanobenzothiazolePC3M-luc cellsInhibitorinhibitorinhibit

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