2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE11A4-IN-2

PDE11A4-IN-2 是一种选择性 PDE11A4 抑制剂，IC50 为 33 nM。PDE11A4-IN-2 可在细胞模型中功能性抑制 PDE11A4 介导的 cAMP 和 cGMP 的催化活性。PDE11A4-IN-2 可用于年龄相关认知衰退的研究。

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PDE11A4-IN-2

PDE11A4-IN-2 Chemical Structure

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PDE11A4-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline[1].

IC50 & Target[1]

PDE11A4

33 nM (IC50)

体外研究
(In Vitro)

PDE11A4-IN-2 (compound 15c) 在小鼠肝微粒体中具有中等稳定性，半衰期为 25 min[1]。
PDE11A4-IN-2 (0.1-100 μM) 可在过表达 PDE11A4 的小鼠 HT22 海马神经元细胞中浓度依赖性地抑制 cAMP 和 cGMP 介导的 PDE11A4 催化活性，其 EC50 值分别为 10.2 μM 和 10.4 μM，且不会改变 PDE11A4 的蛋白水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PDE11A4-IN-2 相关抗体:
分子量

430.48

Formula

C23H23FN8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PDE11A4-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE11A4-IN-2Phosphodiesterase (PDE)cGMPcAMPneuronal cellsHT22 cellsPDE11A4age-related cognitive declineInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-181589
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