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  3. Biochemical Assay Reagents
  4. Penetratin-Cys

Penetratin-Cys 是一种 Antennapedia Peptide (HY-P0307) 经 C 端半胱氨酸修饰的细胞穿透肽。Penetratin-Cys 可作为细胞毒素，降低分化神经元细胞的活力。Penetratin-Cys 可定位于核周并与高尔基体结合。Penetratin-Cys 可用于神经系统疾病的相关研究。

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Penetratin-Cys

Penetratin-Cys Chemical Structure

CAS No. : 393511-85-8

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Other Forms of Penetratin-Cys:

Penetratin-Cys 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders[1].

体外研究
(In Vitro)

Penetratin-Cys 二聚体 (50-400 μg/mL; 24 h) 在 400 μg/mL 浓度下对分化型 SH-SY5Y 细胞表现出强细胞毒性，在测试浓度范围内对 HeLa 细胞和未分化型 SH-SY5Y 细胞表现出中等细胞毒性[1]。
Penetratin-Cys 二聚体 (7 μM/liter; 2-24 h) 可高效进入 HeLa 细胞，孵育 24 h 后定位于与高尔基体相关的核周区域[1]。
Penetratin-Cys 二聚体 对 E. coli、M. luteus 和 S. aureus 表现出微弱的抗菌活性，其 MIC 值根据菌株不同在 8 μmol/liter 至>32 μmol/liter 之间波动[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Penetratin-Cys 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: HeLa, undifferentiated SH-SY5Y, differentiated SH-SY5Y
Concentration: 50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL
Incubation Time: 24 h
Result: Reduced HeLa cell viability to levels below 60% at 400 μg/mL.
Reduced undifferentiated SH-SY5Y cell viability to levels similar to penetratin-PrAMP constructs at 200 μg/mL.
Reduced differentiated SH-SY5Y cell viability to ~30% at 400 μg/mL.

Immunofluorescence[1]

Cell Line: HeLa
Concentration: 7 μM/liter
Incubation Time: 2 h, 24 h
Result: Entered HeLa cells and aligned perinuclear in small distinct spots after 2 h.
Formed a dense cloud associated with the Golgi apparatus after 24 h.
分子量

2349.87

Formula

C107H173N35O21S2
CAS 号
Sequence

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys
Sequence Shortening

RQIKIWFQNRRMKWKKC
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Penetratin-Cys 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penetratin-Cys393511-85-8Biochemical Assay ReagentsEscherichia coliGolgi apparatusdifferentiated neuronal cellsStaphylococcus aureusHeLa cellsproline-rich antimicrobial peptidesSH-SY5Y cellsMicrococcus luteusGram-positive bacteriabacterial infectionsInhibitorinhibitorinhibit

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