2. Apoptosis
  3. Apoptosis
  4. Perforin-IN-3

Perforin-IN-3 是一种特异性穿孔素抑制剂，通过阻断穿孔素介导的溶细胞孔形成及随后的细胞裂解。Perforin-IN-3 有效抑制 NK 细胞对白血病等靶细胞的杀伤作用，且不干扰 FasL 或 TRAIL 介导的细胞死亡途径。Perforin-IN-3 不影响肺炎溶血素 (pneumolysin)，可用于研究自身免疫性疾病、同种异体移植排斥反应、移植物抗宿主病及家族性噬血细胞性淋巴组织细胞增生综合征。

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Perforin-IN-3

Perforin-IN-3 Chemical Structure

CAS No. : 178970-88-2

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Perforin-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Perforin-IN-3 is a specific perforin inhibitor that blocks perforin-mediated lytic pore formation and subsequent cell lysis. Perforin-IN-3 potently inhibits the killing effect of NK cells on target cells such as leukemia cells, without interfering with FasL- or TRAIL-mediated cell death pathways. Perforin-IN-3 has no effect on pneumolysin and can be used to study autoimmune diseases, allograft rejection, graft-versus-host disease, and familial hemophagocytic lymphohistiocytosis[1].

体外研究
(In Vitro)

Perforin-IN-3 (compound 1) 可抑制穿孔素介导的 Jurkat T 淋巴瘤细胞裂解，IC50 (4 h) 为 2.7 μM[1]。
Perforin-IN-3 可将 KHYG-1 NK 细胞介导的 K562 白血病靶细胞杀伤率抑制 50%，且暴露处理 24 h 后 KHYG-1 NK 细胞的存活率仍保持 72%[1]。
Perforin-IN-3 (20 μM; 30 min) 不抑制 Fas 配体或 TRAIL 介导的 Jurkat T 淋巴瘤细胞死亡[1]。
Perforin-IN-3 可将原代人 NK 细胞介导的 K562 白血病靶细胞裂解抑制 70% 以上[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Perforin-IN-3 相关抗体:
分子量

273.31

Formula

C14H11NO3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Perforin-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perforin-IN-3178970-88-2Apoptosisleukemia target cellsautoimmune diseasesNK cellsgraft-versus-host diseaseperforinFasLT-lymphoma cellsTRAILallograft rejectionpneumolysinInhibitorinhibitorinhibit

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