2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK JAK/STAT Signaling PI3K/Akt/mTOR
  3. Antibody-Drug Conjugates (ADCs) EGFR PI3K mTOR
  4. Pertuzumab-LD3

Pertuzumab-LD3 是一种靶向 HER2 的人源化抗体药物偶联物 (ADC)。Pertuzumab-LD3 由抗 HER2 人源化 IgG1 单克隆抗体帕妥珠单抗 (HY-P9912)、可裂解连接子 Gly-Gly-Phe-Gly (HY-P3669) 和 PI3K/mTOR-IN-21 (HY-185456) 有效载荷组成。Pertuzumab-LD3 可用于转移性 HER2 阳性乳腺癌的研究。
(粉色: 靶蛋白配体；蓝色: E3 连接酶配体；黑色: 连接子)。

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Pertuzumab-LD3

Pertuzumab-LD3 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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Pertuzumab-LD3 相关抗体

Top Publications Citing Use of Products

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

生物活性

Pertuzumab-LD3 is a humanized antibody-drug conjugate (ADC) targeting HER2. Pertuzumab-LD3 consists of the anti-HER2 humanized IgG1 monoclonal antibody Pertuzumab (HY-P9912), the cleavable linker Gly-Gly-Phe-Gly (HY-P3669), and the PI3K/mTOR-IN-21 (HY-185456) payload. Pertuzumab-LD3 can be used in research on metastatic HER2-positive breast cancer. (Pink: Target protein ligand; Blue: E3 ligase ligand; Black: linker).

IC50 & Target

HER2

 

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Pertuzumab-LD3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pertuzumab-LD3Antibody-Drug Conjugates (ADCs)EGFRPI3KmTORAntibody-Drug ConjugatesEpidermal growth factor receptorErbB-1HER1Phosphoinositide 3-kinaseMammalian target of RapamycinInhibitorinhibitorinhibit

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