2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. PF-00446687 hydrochloride

PF-00446687 hydrochloride 是一种有效的，脑渗透性的，选择性黑皮质素 4 受体 (MC4R) 激动剂，EC50 为 12  nM。PF-00446687 hydrochloride 可用于性功能障碍研究。

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PF-00446687 hydrochloride

PF-00446687 hydrochloride Chemical Structure

CAS No. : 862282-10-8

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PF-00446687 hydrochloride 的其他形式现货产品:

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Other Forms of PF-00446687 hydrochloride:

PF-00446687 hydrochloride 相关抗体

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查看 Melanocortin Receptor 亚型特异性产品:

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MC1R MC3R MC2R MC4R MC5R

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-00446687 hydrochloride is a potent, brain-penetrating, selective melanocortin 4 receptor (MC4R) agonist with an EC50 of 12 nM. PF-00446687 hydrochloride can be used in the research of sexual dysfunction[1][2].

IC50 & Target[1][2]

MC4R

12 nM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO EC50
1.16 μM
Compound: 40a
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assay
[PMID: 20329799]
CHO EC50
12 nM
Compound: 40a
Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay
Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assay
[PMID: 20329799]
HEK293 EC50
1.02 μM
Compound: 40a
Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay
Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assay
[PMID: 20329799]
HEK293 EC50
1.98 μM
Compound: 40a
Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay
Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assay
[PMID: 20329799]
分子量

507.06

Formula

C28H37ClF2N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-00446687 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-00446687862282-10-8PF00446687PF 00446687Melanocortin ReceptorMC Receptorsexual dysfunctionInhibitorinhibitorinhibit

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产品名称：
PF-00446687 hydrochloride
目录号：
HY-10623
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