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  3. Drug Intermediate
  4. PF-06862309

PF-06862309 是 PF-06843195 (HY-131972) 的磷酸酯前药。PF-06862309 在碱性磷酸酶的作用下可水解为 PF-06843195。PF-06843195 是一种高选择性 PI3Kα 抑制剂。PF-06862309 可用于研究 ER+、HER2- 和 PIK3CA 突变的乳腺癌。

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PF-06862309

PF-06862309 Chemical Structure

CAS No. : 2067281-52-9

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PF-06862309 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-06862309 is a PF-06843195 (HY-131972) phosphate ester prodrug. PF-06862309 can be hydrolyzed to PF-06843195 in the presence of alkaline phosphatase. PF-06843195 is a highly selective PI3Kα inhibitor. PF-06862309 can be used for the study of breast cancer with ER+, HER2-, and PIK3CA mutations[1].

分子量

578.44

Formula

C20H26F3N8O7P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-06862309 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-068623092067281-52-9PF06862309PF 06862309Drug IntermediateDrug Iintermediatephosphate ester prodrug of PF-06843195breast cancer with ER+HER2-and PIK3CA mutationsInhibitorinhibitorinhibit

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产品名称：
PF-06862309
目录号：
HY-138302
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