2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. PF-670462

PF-670462 是一种选择性 CKI ε/δ 抑制剂。PF-670462 能有效调节昼夜节律的相位。

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CAS No. : 950980-98-0

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PF-670462 的其他形式现货产品:

Customer Review

Other Forms of PF-670462:

PF-670462 相关抗体

Top Publications Citing Use of Products

    PF-670462 purchased from MCE. Usage Cited in: Biochem Biophys Res Commun. 2020 Mar 12;523(3):809-815.  [Abstract]

    Immunoblot analysis of cells treated with IC261 or PF670462 for 48 h. GAPDH served as a loading control.

    PF-670462 purchased from MCE. Usage Cited in: Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7522-E7531.   [Abstract]

    CK1ε phosphorylates LRP6 at Thr1479 in vitro and TPA enhances the kinase activity of CK1ε. GST-LRP6 mini fragment fusion protein is incubated with recombinant CK1ε in the presence of 200 μM ATP with or without 160 μM TPA or 2 μM PF670462 as indicated.

    查看 Casein Kinase 亚型特异性产品:

    查看所有亚型
    CK1 CK2

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    PF-670462 is a selective CKI ε/δ inhibitor. PF-670462 effectively regulates the phase of the circadian rhythm[1].

    IC50 & Target[1]

    CK1δ

     

    CK1ε

     

    细胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    COS-7 IC50
    80.5 nM
    Compound: 1, PF-670462
    Inhibition of human CK1 delta transfected in african green monkey cos7 cells after overnight incubation by whole cell assay
    Inhibition of human CK1 delta transfected in african green monkey cos7 cells after overnight incubation by whole cell assay
    		[PMID: 23919824]
    Caco-2 CC50
    8.24 μM
    Compound: PF-670462
    Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
    Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay
    		10.21203/rs.3.rs-23951/v1
    Caco-2 IC50
    19.23 μM
    Compound: PF-670462
    Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
    Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging
    		10.21203/rs.3.rs-23951/v1
    分子量

    337.39

    Formula

    C19H20FN5
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    PF-670462 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    PF-670462950980-98-0PF670462PF 670462Casein Kinasecircadian rhythmInhibitorinhibitorinhibit

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    产品名称：
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    目录号：
    HY-15490A
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