2. Metabolic Enzyme/Protease Anti-infection
  3. Proteasome Parasite
  4. Pf20S-IN-1

Pf20S-IN-1 是一种恶性疟原虫 (Plasmodium falciparum) 20S 蛋白酶体 β5 亚基选择性抑制剂。Pf20S-IN-1 对恶性疟原虫具有抗寄生虫活性，对 Plasmodium falciparum W2 株的 EC50 为 20.1 nM。Pf20S-IN-1 对人源 20S 蛋白酶体抑制微弱，对人包皮成纤维细胞 (HFF) 无明显毒性，选择性指数 > 25000。Pf20S-IN-1 可用于疟疾研究。

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Pf20S-IN-1

Pf20S-IN-1 Chemical Structure

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Pf20S-IN-1 相关抗体

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC50 of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research[1].

IC50 & Target[1]

Plasmodium

 

体外研究
(In Vitro)

Pf20S-IN-1 (1 nM-10 μM; 72 h) 可强效抑制恶性疟原虫 W2 细胞的生长，其 EC50 为 20.1 nM，且针对人包皮成纤维细胞的选择性指数 ＞ 25000[1]。
Pf20S-IN-1 (30 min preincubation, 3 h kinetic assays) 可强效且选择性地抑制纯化的恶性疟原虫 20S 蛋白酶体的 β5 亚基，对人组成型 20S 蛋白酶体 β5 亚基的选择性达 45 倍[1]。
Pf20S-IN-1 可特异性结合恶性疟原虫 20S 蛋白酶体和人组成型 20S 蛋白酶体的 β5 亚基；更有利的氢键相互作用及独特构象使其对 Pf 20S 蛋白酶体具有选择性效力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Pf20S-IN-1 相关抗体:
分子量

623.71

Formula

C33H42FN5O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pf20S-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pf20S-IN-1ProteasomeParasitemalariaThr1 nucleophilePlasmodium falciparum W2 cellhuman cells20S proteasome β5 subunithuman constitutive 20S proteasome β5 subunitPlasmodium falciparumβ1 subunitshydrophobic S1 pocketβ2 subunitsInhibitorinhibitorinhibit

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HY-183009
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