2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. PHD-1-IN-2

PHD-1-IN-2 是一种具有口服活性的缺氧诱导因子脯氨酰羟化酶结构域 1 (PHD-1) 抑制剂，IC50 为 0.07 μM。PHD-1-IN-2 是 MDR1-MDCK 细胞单层实验中 MDR1 的底物。PHD-1-IN-2 可用于缺血、炎症反应、神经退行性病变的研究，如：炎症性肠病、缺血再灌注损伤。

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PHD-1-IN-2

PHD-1-IN-2 Chemical Structure

CAS No. : 2009344-53-8

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PHD-1-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HIF/HIF Prolyl-Hydroxylase 亚型特异性产品:

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HIF-1α HIF

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PHD-1-IN-2 is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase domain 1 (PHD-1) with an IC50 of 0.07 μM. PHD-1-IN-2 acts as a substrate of MDR1 in MDR1-MDCK cell monolayer assays. PHD-1-IN-2 can be used in the research of ischemia, inflammatory responses and neurodegenerative diseases, such as inflammatory bowel disease and ischemia-reperfusion injury[1].

体外研究
(In Vitro)

PHD-1-IN-2 (Compound 54) 是 MDR1-MDCK 细胞单层中由 MDR1 介导外排的底物，外排率为 99[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PHD-1-IN-2 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route CL AUC0-t Cmax Bioavailability
Mice[1] 3 mg/kg p.o. / 3658 ng·h/mL 5 μM 100 %
Mice[1] 0.5 mg/kg i.v. 17.5 mL/min/kg / / /
分子量

291.31

Formula

C16H13N5O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PHD-1-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHD-1-IN-22009344-53-8HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHPHD-1 Inhibitorischemiainflammatory responsesneurodegenerative diseasesInhibitorinhibitorinhibit

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