2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Bcr-Abl
  4. Phe-PEG1-Dasa

Phe-PEG1-Dasa 是一种 BCR-ABL PROTAC 降解剂，其 DC50 为 1.56 nM。Phe-PEG1-Dasa 将单个氨基酸 (Phe) 作为 E3 连接酶配体，利用 N-end rule 通路来诱导目标蛋白降解，显著减小了分子尺寸，因此被称为 mini-PROTAC。Phe-PEG1-Dasa 显著抑制 K562 细胞的增殖。Phe-PEG1-Dasa 可用于研究白血病。
(粉色: Bcr-Abl 配体 (HY-10181)；蓝色: Ligands for E3 Ligase 配体 (HY-N0215)；黑色: 连接子)。

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Phe-PEG1-Dasa

Phe-PEG1-Dasa Chemical Structure

CAS No. : 3037776-73-8

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Phe-PEG1-Dasa 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Abl Bcr-Abl

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Phe-PEG1-Dasa is a BCR-ABL PROTAC degrader, with its DC50 being 1.56 nM. Phe-PEG1-Dasa uses a single amino acid (Phe) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, thus being called a mini-PROTAC. Phe-PEG1-Dasa significantly inhibits the proliferation of K562 cells. Phe-PEG1-Dasa can be used for the study of leukemia[1]. (Pink: Bcr-Abl ligand (HY-10181); Blue: Ligands for E3 Ligase ligand (HY-N0215); Black: linker).

IC50 & Target[1]

Bcr-Abl

1.56 nM (DC50)

分子量

750.31

Formula

C36H44ClN9O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Phe-PEG1-Dasa 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phe-PEG1-Dasa3037776-73-8PROTACsBcr-AblPROTACN-end rule pathwayDegronmini-PROTACLinker-freeAmino acidsUbiquitin ligaseInhibitorinhibitorinhibit

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